Carbenicillin was introduced in therapeutics in 1967 and was especially useful, on its own or when associated with aminoglycosides, for the treatment of infections caused by Pseudomonas aeruginosa (23), a well-recognized nosocomial pathogen with intrinsic resistance to various antimicrobial agents and the ability to develop multidrug resistance (18). Nevertheless, an increasing frequency of P. ...

In Brazil, carbapenem-resistant Pseudomonas aeruginosa isolates are closely related to the São Paulo metallo-β-lactamase (SPM) Brazilian clone. In this study, imipenem-resistant isolates were divided in two sets, 2002/2003 and 2008/2009, analysed by pulsed field gel electrophoresis and tested for the Ambler class B metallo-β-lactamase (MBL) genes blaSPM-1, blaIMP and blaVIM. The results show a ...

United Kingdom, the Netherlands, France, New Zealand, Oman, and Singapore (8). It has also been found to be associated with other carbapenemase genes, such as the blaNDM-1 and blaVIM-5 genes, and particularly in isolates with a link to the Indian subcontinent. In the cases we describe, the first K. pneumoniae isolate was recovered from a patient transferred from the UAE. Recent studies suggest ...

Vol. 7, No. 5, September-October 2001 911 Emerging Infectious Diseases (blaPER-1 and blaVIM-2 ) had been detected separately among clinical isolates, underscores the possibility of the emergence of new threatening combinations of resistance determinants among nosocomial pathogens. In fact, the recruitment of similar resistance determinants within a single P. aeruginosa strain can determine a re...

background and objectives : carbapenem resistant pseudomonas aeruginosa is a serious cause of nosocomial infections.the main purpose of the study is to determine the prevalence rate of imipenem resistant pseudomonas aeruginosa carrying metallo- beta- lactamase (mbl) genes. material and methods : 236 pseudomonas aeruginosa isolates were collected from teaching hospitals of ahvaz university of me...