Tissue-specific stem cells combine proliferative and asymmetric divisions to balance self-renewal with differentiation. Tight regulation of the orientation and plane of cell division is crucial in this process. Here, we study the reproducible pattern of anterior-posterior-oriented stem cell-like divisions in the Caenorhabditis elegans seam epithelium. In a genetic screen, we identified an alg-1...

During each life cycle, gametes must preserve and pass on both genetic and epigenetic information, making the germline both immortal and totipotent. In the male germline the dramatic morphological transformation of a germ cell through meiosis, into a sperm competent for fertilization, while retaining this information is an incredible example of cellular differentiation. This process of spermato...

Bu çal??man?n amac?, i?letmelerde iç denetimin etkinlik düzeyini belirlemek ve belirlenen denetim düzeylerinin i?letme verimlili?ine etkisine ili?kin yönetici alg?lar?n?n ara?t?r?lmas?d?r. ?ç di?er alanlara etkisi incelenirken, öncelikle etkin bir ?ekilde uyguland???ndan emin olunmas? gereklidir. Çal??mada, literatürdeki bu bo?luk doldurulmaya çal???larak etkisini ara?t?rmak için çal??ma kapsam...

BACKGROUND At the University Hospital Zurich (USZ) and the Cantonal Hospital of Lucerne (LUKS) an individualized goal-directed coagulation and transfusion algorithm was introduced and implemented before 2012 (Coagulation algorithm of the USZ: USZ-Alg; of the LUKS: LUKS-Alg). Main differences between both algorithms are: 1) A target haematocrit-range of 0.21-0.24 (USZ-Alg) vs. a lower haematocri...

In this article, a hybrid gel has been developed using sodium alginate (Alg) and α-tricalcium phosphate (α-TCP) particles through ionic crosslinking process for the application in bone tissue engineering. The effects of pH and composition of the gel on osteoblast cells (MC3T3) response and bioactive molecules release have been evaluated. At first, a slurry of Alg and α-TCP has been prepared usi...

The question was examined as to whether immunosuppression in a rat model system would affect the carcinogenic processes leading to tumors in the liver and the large bowel. The protocols were designed to detect an increased incidence or a shorter latent period stemming from a change in immune status. Groups of rats were given injections prior to initiation of the carcinogen regimen and continuou...

Based on the results of Blum, Shub and Smale 1], Meer 5], Cucker and Matamala 3] and Koiran 7], we develop the study of real computation models restricted to additive operations. More speciically we introduce some complexity classes deened by algebraic circuits and we study their relationships with the real computation model. We show that the languages accepted by nonuniform additive circuits o...

Cette contribution aborde la mobilisation citoyenne initiée en Algérie le 22 février 2019 déconstruisant les représentations, telles qu’elles ont prévalu dans discours politiques et travaux sciences sociales, d’une société dépolitisée enfermée traumatisme des années 1990. Elle démontre que Hirak est l’expres...

We prove an analogue of the Lindemann-Weierstrass theorem (that the exponentials of a Q-linearly independent set of algebraic numbers are algebraically independent), replacing Qalg by C(t)alg, and Gm by a semiabelian variety over C(t) alg. Both the formulations of our results and the methods are differential algebraic in nature.

A category is said to be alg-universal, if every category of universal algebras can be fully embedded into it. We prove here that the category of varieties and interpretations, or in other words, the category of abstract clones and clone homomorphisms, is alg-universal.