We describe a case of untreated adult-onset Coats' disease with a proliferative epiretinal membrane (ERM) treated successfully with 25-gauge pars plana vitrectomy (25GPPV). A 26-year-old man presented with a 3-week history of decreased vision in his left eye. At the initial examination, the decimal best-corrected visual acuity (BCVA) was 0.7 in the left eye. Ophthalmoscopy revealed the typical ...

Throughout life, newly generated neuroblasts from the subventricular zone migrate toward the olfactory bulb through the rostral migratory stream. Upon brain injury, these migrating neuroblasts change their route and begin to migrate toward injured regions, which is one of the regenerative responses after brain damage. This injuryinduced migration is triggered by stromal cell-derived factor 1 (S...

OBJECTIVE To determine the relationship between the morphology of the fovea and visual acuity in patients with an untreated idiopathic epiretinal membrane (ERM). METHODS We examined 52 eyes of 45 patients diagnosed with an ERM. The morphology of the foveal area was determined by spectral-domain optical coherence tomography. The relationships between the best-corrected visual acuity (BCVA) and...

In today’s challenging global economy, risk management is encountering a significant transformation. Organizations are switching their method to enterprise-wide from the traditional compartmentalized approach. Enterprise (ERM), which aims at increasing sustainability of an organization and achieving competitive advantage, gaining attention fast becoming essential concern in all industries. Desp...

Hyperosmotic shrinkage induces multiple cellular responses, including activation of volume-regulatory ion transport, cytoskeletal reorganization, and cell death. Here we investigated the possible roles of ezrin/radixin/moesin (ERM) proteins in these events. Osmotic shrinkage of Ehrlich Lettre ascites cells elicited the formation of long microvillus-like protrusions, rapid translocation of endog...

Background/aim: The mechanisms of the cellular origin and cell proliferation in the idiopathic epiretinal membrane (ERM) are unsolved. The aim of this study was to examine the expression of cell cycle related molecules and glutamine synthetase (GS), which is expressed in Müller cells and their processes, in ERM tissues. Methods: The ERMs were surgically removed using pars plana vitrectomy. Form...

BACKGROUND AND OBJECTIVE To determine whether the volumes of macular layers before and after epiretinal membrane (ERM) peeling as measured by spectral-domain optical coherence tomography (SD-OCT) correlated with best-corrected visual acuity (BCVA) or ERM location. PATIENTS AND METHODS Thirty-six eyes with idiopathic ERM and 12 control eyes were imaged preoperatively and postoperatively using ...

Risk Management (RM) is rapidly evolving; its practitioners are increasingly shifting focus from pure operational or financial risks to a broader Enterprise Risk Management (ERM). ERM involves a set of processes and methods used to manage risks that are not just associated with accidental losses but also associated with financial, strategic, technological and other business areas. This article ...

PEA3, ERM and ER81 belong to the PEA3 subfamily of Ets transcription factors and play important roles in a number of tissue-specific processes. Transcriptional activation by PEA3 subfamily factors requires their characteristic amino-terminal acidic transactivation domain (TAD). However, the cellular targets of this domain remain largely unknown. Using ERM as a prototype, we show that the minima...

Cell polarization is a key feature of cell motility, driving cell migration to tissues. CD43 is an abundantly expressed molecule on the T-cell surface that shows distinct localization to the migrating T-cell uropod and the distal pole complex (DPC) opposite the immunological synapse via association with the ezrin-radixin-moesin (ERM) family of actin regulatory proteins. CD43 regulates multiple ...