نتایج جستجو برای: چارچوب gof

تعداد نتایج: 18532  

Journal: :R Journal 2021

Last decades show an increased interest in modeling various types of data through copulae. Different copula models have been developed, which lead to the challenge finding best fitting model for a particular dataset. From other side, strand literature developed list different Goodness-of-Fit (GoF) tests with powers under conditions. Usual practice is selection via p-value GoF test. Although thi...

2014
Pedro W. Crous Alejandra Giraldo David L. Hawksworth Vincent Robert Paul M. Kirk Josep Guarro Barbara Robbertse Conrad L. Schoch Ulrike Damm Thippawan Trakunyingcharoen Johannes Z. Groenewald

To ensure a stable platform for fungal taxonomy, it is of paramount importance that the genetic application of generic names be based on their DNA sequence data, and wherever possible, not morphology or ecology alone. To facilitate this process, a new database, accessible at www.GeneraofFungi.org (GoF) was established, which will allow deposition of metadata linked to holo-, lecto-, neo- or epi...

2011
Barbara Hämmerle Edgar Ulin Jordi Guimera Walter Becker François Guillemot Francisco J. Tejedor

The decision of a neural precursor to stop dividing and begin its terminal differentiation at the correct place, and at the right time, is a critical step in the generation of cell diversity in the nervous system. Here, we show that the Down’s syndrome candidate Mnb/Dyrk1A gene is transiently expressed in prospective neurons of vertebrate CNS neuroepithelia. The gain of function (GoF) of Mnb/Dy...

Journal: :PLoS Pathogens 2009
Sélène Ferrari Françoise Ischer David Calabrese Brunella Posteraro Maurizio Sanguinetti Giovanni Fadda Bettina Rohde Christopher Bauser Oliver Bader Dominique Sanglard

CgPdr1p is a Candida glabrata Zn(2)-Cys(6) transcription factor involved in the regulation of the ABC-transporter genes CgCDR1, CgCDR2, and CgSNQ2, which are mediators of azole resistance. Single-point mutations in CgPDR1 are known to increase the expression of at least CgCDR1 and CgCDR2 and thus to contribute to azole resistance of clinical isolates. In this study, we investigated the incidenc...

Journal: :Development 2011
Barbara Hämmerle Edgar Ulin Jordi Guimera Walter Becker François Guillemot Francisco J Tejedor

The decision of a neural precursor to stop dividing and begin its terminal differentiation at the correct place, and at the right time, is a crucial step in the generation of cell diversity in the nervous system. Here, we show that the Down's syndrome candidate gene (Mnb/Dyrk1a) is transiently expressed in prospective neurons of vertebrate CNS neuroepithelia. The gain of function (GoF) of Mnb/D...

2014
Chien-Ya Hung Pei-Lun Sun Shu-Jen Chiang Fu-Shan Jaw

BACKGROUND Similar clinical appearances prevent accurate diagnosis of two common skin diseases, clavus and verruca. In this study, electrical impedance is employed as a novel tool to generate a predictive model for differentiating these two diseases. MATERIALS AND METHODS We used 29 clavus and 28 verruca lesions. To obtain impedance parameters, a LCR-meter system was applied to measure capaci...

2017
Ofer Zimmerman Lindsey B. Rosen Muthulekha Swamydas Elise M. N. Ferre Mukil Natarajan Frank van de Veerdonk Steven M. Holland Michail S. Lionakis

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare primary immunodeficiency disorder typically caused by biallelic autoimmune regulator (AIRE) mutations that manifests with chronic mucocutaneous candidiasis (CMC) and autoimmunity. Patients with STAT1 gain-of-function (GOF) mutations also develop CMC and autoimmunity; they exhibit increased STAT1 protein levels at ...

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