Background: Follicular lymphoma (FL) is the most prevalent indolent B-cell non-Hodgkin (B-NHL). Progression of disease within 24 months (POD24) and transformation to large (LBCL) are known adverse outcomes in grade 1–2 FL. There a need develop practical sensitive biomarkers risk-stratify these patients (pts) at diagnosis. Ki-67 staining widely available biomarker without defined role FL, howeve...

A novel perichromosomal protein, which we have named chmadrin, was identified from rat kangaroo PtK2 cells. The deduced amino acid sequence revealed structural homologies in several limited regions to the Ki-67 antigen (pKi-67). The subcellular localization of chmadrin was found to be similar to that of pKi-67 throughout the cell cycle, that is, predominantly nucleolar during interphase and per...

Insertion of a crude preparation of cyclic AMP (cAMP)-dependent protein kinase inhibitor (PKI) into a cloned mouse anterior pituitary cell line (AtT-20/D16-16) blocked cAMP-mediated hormone release. This was accomplished by developing a technique to incorporate PKI into multicellular cultures. The technique involved the encapsulation of the PKI into liposomes coupled to Protein A (a bacterial p...

Protein kinase inhibitor (PKI) is a potent endogenous inhibitor of the cyclic AMP (cAMP)-dependent protein kinase (PKA). It functions by binding the free catalytic (C) subunit with a high affinity and is also known to export nuclear C subunit to the cytoplasm. The significance of these actions with respect to PKI's physiological role is not well understood. To address this, we have generated by...

OpenPGP, an IETF Proposed Standard based on PGP R © application, has its own Public Key Infrastructure (PKI) architecture which is different from the one based on X.509, another standard from ITU. This paper describes the OpenPGP PKI; the historical perspective as well as its current use. We also compare three PKI technologies standardized by IETF: OpenPGP, PKIX(X.509), and SPKI/SDSI. Since the...

A PKI can be described as a set of technologies, procedures and policies for propagating trust from where it initially exists to where it is needed for authentication in online environments. How the trust propagation takes place under a specific PKI depends on the PKI’s syntactic trust structure which is commonly known as a trust model. However, trust is primarily a semantic concept that can no...