Protoporphyrinogen oxidase (Protox) inhibitors and other com pounds which block o r stim­ ulate the porphyrin pathway can cause sufficient levels o f porphyrins to accum ulate in plant tissues for severe photodynam ic dam age to occur. The gross sym ptom ology for all o f these p o r­ phyrinogenic herbicides is similar. Porphyrin accum ulation induced by three porphyrinogenic herbicides acifluo...

Background: Hypoxia-induced CA IX contributes to pH control in tumor cells, and control of pH is important for cell migration. Result: CA IX increases migration through its catalytic domain and interacts with bicarbonate transporters in lamellipodia. Conclusion: CA IX is an active component of the molecular machinery that facilitates migration of tumor cells through pH regulation at the leading...

The expression of carbonic anhydrase (CA) IX is up-regulated in many types of solid tumors in humans under hypoxic and acidic microenvironment. Inhibition of CA IX enzymatic activity with selective inhibitors, antibodies or labeled probes has been shown to reverse the acidic environment of solid tumors and reduce the tumor growth establishing the significant role of CA IX in tumorigenesis. Thus...

DNA from nine hemophilia B patients who produce anti-factor IX inhibitors (antibodies), including two brothers, was analyzed by the Southern blotting method and hybridization with factor IX cDNA, intragenomic, and 3'-flanking probes. Two inhibitor patients were shown to have total deletions of the factor IX gene. Two other inhibitor patients, the brothers, were shown to have a presumably identi...

Carbonic anhydrase (CA) II, CA IX, and CA XII are expressed in various neoplasias and have been linked to tumorigenesis. We examined their expression in three different groups of colorectal cancer [i.e., microsatellite stable (MSS), microsatellite instable (MSI), and hereditary nonpolyposis colorectal cancer (HNPCC)]. First, we analyzed gene expression profiles of 113 specimens by a microarray ...

The intraerythrocytic Plasmodium falciparum parasite converts most of host hemoglobin heme into a nontoxic heme crystal. Erythrocyte zinc protoporphyrin IX, normally present at 0.5 microM, which is a ratio of 1:40,000 hemes, can elevate 10-fold in some of the anemias associated with malaria disease protection. This work examines a binding mechanism for zinc protoporphyrin IX inhibition of heme ...

Besides hypoxia, other factors and molecules such as lactate, succinate, and reactive oxygen species activate transcription factor hypoxia-inducible factor-1 (HIF-1) even in normoxia. One of the main target gene products of HIF-1 is carbonic anhydrase IX (CA IX). CA IX is overexpressed in many tumors and serves as prognostic factor for hypoxic, aggressive and malignant cancers. CA IX is also in...

Thrombin decreases the platelet surface expression of the glycoprotein (GP) Ib-IX complex. To determine whether this effect is reversible, flow cytometric studies were performed with GPlb-IX-specific monoclonal antibodies. In both whole blood and washed platelet systems, incubation of platelets with thrombin or a combination of adenosine diphosphate and epinephrine resulted in a maximal decreas...

background: as glass ionomers have the ability to reload fluoride from outside sources, the aim was to compare the recharge pattern of six glass ionomer cements after exposure to fluoride. materials and methods: fuji vii, fuji ix, riva pink, riva bleach, ketac fil and fuji ix extra were investigated. the fluoride-containing materials used were tooth paste and mouth wash (colgate). specimens of ...

vii Preface ix Acknowledgements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix Publications during doctorate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi