نتایج جستجو برای: پروتئین hsp40
تعداد نتایج: 18516 فیلتر نتایج به سال:
DNAJC25 gene is a member of the HSP40 (DNAJ) family, and it was suggested as tumor suppressor in hepatocellular carcinoma. The aim this study to analyze expression, genetic/epigenetic alterations, prognostic value breast cancer. transcript levels are upregulated BT-20 ZR-75-1 cell lines downregulated MDA-MB-231 line compared non-tumorigenic mammary epithelial (MCF 10A) (P< 0.05). According U...
Molecular chaperones reside in nearly every organelle within a eukaryotic cell, and in each of these compartments, they ensure that protein homeostasis (or proteostasis) is maintained. In this issue, Wiseman and colleagues find that an ER lumenal chaperone escapes this compartment when a specific stress pathway is activated. The chaperone, an Hsp40 homolog known as ERdj3, transits through the s...
We report here the mapping of a chromosomal region responsible for strain-specific development of congenital hypothyroidism in mice heterozygous for null mutations in genes encoding Nkx2-1/Titf1 and Pax8. The two strains showing a differential predisposition to congenital hypothyroidism contain several single-nucleotide polymorphisms in this locus, one of which leads to a nonsynonymous amino ac...
The role of bacterial Hsp40, DnaJ, is to co-chaperone the binding of misfolded or alternatively folded proteins to bacterial Hsp70, DnaK, which is an ATP-fuelled unfolding chaperone. In addition to its DnaK targeting activity, DnaJ has a weak thiol-reductase activity. In between the substrate-binding domain and the J-domain anchor to DnaK, DnaJ has a unique domain with four conserved CXXC motiv...
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