Regulation of chromatin is a key process in the developmental control of gene expression. Many multi-subunit protein complexes have been found to regulate chromatin through the modification of histone residues. One such complex is the MOF histone acetyltransferase-containing NSL complex. While the composition of the human and Drosophila NSL complexes has been determined and the functions of the...

Due to the increasing cyber-attacks, various Intrusion Detection Systems (IDSs) have been proposed identify network anomalies. Most existing machine learning-based IDSs learn patterns from features extracted traffic flows, and deep approaches can data distribution raw differentiate normal anomalous flows. Although having used in real world widely, above methods are vulnerable some types of atta...

Intrusion detection systems are designed to provide security in computer networks, so that if the attacker crosses other security devices, they can detect and prevent the attack process. One of the most essential challenges in designing these systems is the so called curse of dimensionality. Therefore, in order to obtain satisfactory performance in these systems we have to take advantage of app...

Intrusion detection systems are designed to provide security in computer networks, so that if the attacker crosses other security devices, they can detect and prevent the attack process. One of the most essential challenges in designing these systems is the so called curse of dimensionality. Therefore, in order to obtain satisfactory performance in these systems we have to take advantage of app...

The NSL Neural Simulation Language provides a platform for building neural architectures (modeling) and for executing them (simulation). NSL is based on object-oriented technology and provides modularity at all model development levels. In this chapter we discuss these basic concepts and how NSL takes advantage of them. NSL, now in its third major release, is a neural network simulator which is...

hMOF (MYST1), a histone acetyltransferase (HAT), forms at least two distinct multiprotein complexes in human cells. The male specific lethal (MSL) HAT complex plays a key role in dosage compensation in Drosophila and is responsible for histone H4K16ac in vivo. We and others previously described a second hMOF-containing HAT complex, the non-specific lethal (NSL) HAT complex. The NSL complex has ...

The MOF (males absent on the first)-containing NSL (non-specific lethal) complex binds to a subset of active promoters in Drosophila melanogaster and is thought to contribute to proper gene expression. The determinants that target NSL to specific promoters and the circumstances in which the complex engages in regulating transcription are currently unknown. Here, we show that the NSL complex pri...

Localized surface plasmon resonance (LSPR) is the coherent oscillation of conductive electrons confined in noble metallic nanoparticles excited by electromagnetic radiation, and nanosphere lithography (NSL) is one of the cost-effective methods to fabricate metal nanostructures for LSPR. NSL can be categorized into two major groups: dispersed NSL and closely pack NSL. In recent years, gold nanoc...

The histone acetyltransferase (HAT) Mof is essential for mouse embryonic stem cell (mESC) pluripotency and early development. Mof is the enzymatic subunit of two different HAT complexes, MSL and NSL. The individual contribution of MSL and NSL to transcription regulation in mESCs is not well understood. Our genome-wide analysis show that i) MSL and NSL bind to specific and common sets of express...

In recent years, due to the rapid progress of various technologies, wireless computer networks have developed. However, activities security threats and attackers affect data communication these technologies. So, protect network against threats, an efficient IDS (Intrusion Detection System) is presented in this paper. Namely, optimized long short-term memory (OLSTM) with a stacked auto-encoder (...