hpv vaccine has been recently added to the iran drug list, so decision makers need information beyond that available from rcts to recommend funding for this vaccination. modeling and economic studies have addressed some of those information needs. we reviewed cost effectiveness studies to find a suitable model for iranian population to determine the potential cost effectiveness of hpv vaccine p...

background and objectives: breast cancer is the most common malignancy in women throughout the world. there are controversial reports on the role of human papillomavirus (hpv) infection in breast carcinogenesis. the aim of this study was to assess the presence of hpv-dna in invasive breast carcinoma to determine the association between hpv infection and breast carcinoma. methods: the study incl...

objective(s): valproic acid (vpa) has proven to be as one of the most promising useful drug with anticancer properties.in this study, we investigate the vpa effects on e-cadherin expression in hela, tc1, mkn45, and hct116 cell lines.  this study assesses the effects of vpa on human papillomavirus e7 expression in hpv positive cell lines. materials and methods: cell lines were treated by2 mmol/l...

introduction: certain types of human papillomavrus (hpv) are associated with cervical intraepithelial neoplasia (cin) and squamous cell carcinoma (scc). the aim of theobservations reported here was to determine whether the prognosis for invasive cancers of the uterine cervix is related to the type of human papillomavirus asociated with the tumor. material and methods: twenty patients with invas...

the previous studies reported some information about prevalence release of high-risk hpv types in hsil or cervical cancer globally and in iran, however, this information is not enough for final judgment about vaccination against hpv or any screening program. the aim of the present study was to assess the hpv type distribution in hsil and icc specimens of women attending shahid beheshti universi...

Oropharyngeal squamous cell carcinoma (OPSCC) has historically been attributable to tobacco and alcohol exposure saw a decline in incidence after societal norms shifted away from smoking. In recent decades, this disease had re-emergence due human papillomavirus (HPV) infection, now surpassing cervical cancer as the number 1 cause of HPV-related United States. HPV-positive OPSCC differs HPV-nega...

Background: Gastrointestinal (GI) malignancies are the most common cancers and account for nearly half of all cancer-related deaths in Iran. There was a strong association between human papillomavirus (HPV) infection and urogenital cancers, in particular the cervix. However, there is no clear causal relationship in all types of cancers, including gastrointestinal cancers. Therefore, the present...

the purpose of the present study was to estimate the frequency of hpv dna in four groups of oral lesions, including oral squamous cell carcinoma. sixty paraffin-embedded oral tissue samples were examined for the presence of hpv dnas using the pcr technique. these specimens were obtained from patients with oral squamous cell carcinoma (oscc), leukoplakia, oral lichen planus (olp), and pyogenic g...

Abstract Background and Aims: Cervical cancer is among leading causes of cancer related death in women and human papilloma virus (HPV) is one of the important risk factor of this cancer. The aim of the present study was to develop a PCR method for identification of a high carcinogenic type of HPV, HPV 18 using E6 gene as a marker in patients with cervical cancer Materials and Methods: 9...

Objective(s): In the current work, poly D, L lactide-co-glycolide (PLGA) particles were applied for a viral vaccine for the delivery of antigens in cytosolic pathway by increasing the antigen presentation to T-lymphocytes. HPV-E7 protein with PLGA particles has been reported as a potent adjuvant for HPV vaccine by encapsulating protein into the PLGA particles. Polysaccharide from Pleurotus sajo...