Degeneration of CA3-pyramidal neurons in hippocampus after intracerebroventricular kainic acid (KA) administration, a model of temporal lobe epilepsy, results in hyperexcitability within both dentate gyrus and the CA1 subfield. It also leads to persistent reductions in hippocampal glutamate decarboxylase (GAD) interneuron numbers without diminution in Nissl-stained interneuron numbers, indicati...

objective it has previously been shown that prenatal maternal administration of boswellia serrata gum resin (frankincense) improved learning and memory performance associated with an increase in the size of neuronal bodies in ca3 (cornu ammonis) of hippocampus. continuing the previous work, a morphometric study was designed on ca3 field to examine precisely the effect of prenatal administration...

in the current study, we assessed the role of transient receptor potential (trp) channels on avoidance memory and anxiety states in ca3 area of the hippocampus. we explored the anxiety and avoidance memory states using test-retest protocol in the elevated plus maze to understand whether trp channels can affect the above mentioned states in ca3 area. to investigate the consolidation phase of mem...

background and objectives: hippocampal volume reduction has been reported in diabetes mellitus type 1. it is believed that hyperglycemia and oxidative stress mediate neuropathological changes in hippocampal neurons. in this study we aimed to study the effect of insulin and an antioxidant like ascorbic acid on preventing volume changes of dentate gyrus and ca3 region of hippocampus. materials an...

The rate of resorption calcium phosphate self-hardening materials for bone regeneration can be changed by changing the phase composition. Ca3(PO4)2/CaCO3/Ca(H2PO4)2·H2O/Na2HPO4·12H2O system is important synthesis self-curing bioactive with variable rates ratios initial components. Cement compositions in twelve figurative points a four-component composition diagram at fixed content α-Ca3(PO4)2 w...

Different places may share common features, but are coded by distinct populations of CA3 neurons in the hippocampus. Here we show that chemical or genetic suppression of adult neurogenesis in the hippocampus impairs this population-based coding of similar (but not dissimilar) contexts. These data provide a neural basis for impaired spatial discrimination following ablation of adult neurogenesis...

Objective It has previously been shown that prenatal maternal administration of Boswellia serrata gum resin (Frankincense) improved learning and memory performance associated with an increase in the size of neuronal bodies in CA3 (Cornu Ammonis) of hippocampus. Continuing the previous work, a morphometric study was designed on CA3 field to examine precisely the effect of prenatal administratio...

  Background and Objectives: Hippocampal volume reduction has been reported in diabetes mellitus type 1. It is believed that hyperglycemia and oxidative stress mediate neuropathological changes in hippocampal neurons. In this study we aimed to study the effect of insulin and an antioxidant like ascorbic acid on preventing volume changes of dentate gyrus and CA3 region of hippocampus. Material...

The dorsal CA3 region of the hippocampus is unique in its connectivity, sensitivity to neurotoxic lesions, and its ability to encode and retrieve episodic memories. Computational models of the CA3 region predict that blocking mossy-fiber and/or perforant path activity to CA3 would cause impairments in learning and recall of spatial memory, respectively. Because the CA3 region contains micro-opi...