Purpose: To measure the preferences and values of men newly diagnosed with prostate cancer (PC) using a web-based decision support technology—the Decision Support Intervention-Prostate Cancer (DSI-PC). Methods: Health information seeking behaviour, factors having an influence on the treatment decision, decision control, and preferred treatment were recorded by the DSI-PC program prior to the tr...

Background Colposcopy is subjective and management of young patients with high-grade disease is challenging, as treatments may impair subsequent pregnancies and adversely affect obstetric outcomes. Conservative management of selected patients is becoming more popular amongst clinicians; however it requires accurate assessment and documentation. Novel adjunctive technologies for colposcopy could...

The endocannabinoid 2-arachidonoylglycerol (2-AG) mediates retrograde synaptic depression including depolarization-induced suppression of excitation (DSE) and inhibition (DSI). 2-AG is degraded primarily by monoacylglycerol lipase (MAGL), which is expressed in neurons and astrocytes. Using knockout mice in which MAGL is deleted globally or selectively in neurons or astrocytes, we investigated t...

Diffusion spectrum magnetic resonance imaging (DSI) allows the estimation of the displacement probability density function (pdf) of water molecules, which contain valuable information about the microgeometry of the medium where the diffusion process occurs. It provides a more general approach to disentangle complex fiber structures in biological tissues because it does not assume any particular...

Silicon isotope ratios (expressed as δSi) in marine microfossils can provide insights into silica cycling over geologic time. Here we used δSi of sponge spicules and radiolarian tests from the Paleogene Equatorial Transect (Ocean Drilling Program Leg 199) spanning the Eocene and Oligocene (~50–23 Ma) to reconstruct dissolved silica (DSi) concentrations in deep waters and to examine upper ocean ...

The hydrological loading displacements measured by continuous Global Navigation Satellite System (GNSS) networks can provide critical constraints on total terrestrial water storage (TWS) anomalies. We invert sparsely distributed GNSS vertical positions for daily large-scale heights based Slepian basis functions and devise a novel GNSS-based drought severity index (GNSS-DSI) dataset characteriza...

During most of the year, diatom production in ice-covered Central Arctic Ocean (CAO) is limited by light availability and nutrient supply. Therefore, biological thought to be generally low, with higher at sea ice edge over partially ice-free shelf areas. The major surface ocean current CAO Transpolar Drift (TPD), which transports water from rivers shelves Laptev East Siberian Seas across toward...

The plant growth-retardant uniconazole (UNI), a triazole inhibitor of gibberellin biosynthetic enzyme (CYP701A), inhibits multiple P450 enzymes including ABA 8'-hydroxylase (CYP707A), a key enzyme in ABA catabolism. Azole P450 inhibitors bind to a P450 active site by both coordinating to the heme-iron atom via sp2 nitrogen and interacting with surrounding protein residues through a lipophilic r...