Liver microsomes contain two carnitine acyltransferase activities. One of these has properties closely corresponding to those of 88 kDa mitochondrial carnitine palmitoyltransferase-1 (CPT-1). Antisera against CPT-1 cross-react with an 88 kDa microsomal protein, suggesting that CPT-1 may be targeted to both microsomal and mitochondrial membranes. However, no experiments using cDNAs corresponding...

We present a general model-independent and rephase-invariant formalism that cleanly relates CP and CPT noninvariant observables to the fundamental parameters. Different types of CP and CPT violations in the K0-, B0-, B0 s and D 0-systems are explicitly defined. Their importance for interpreting experimental measurements of CP and CPT violations is emphasized. In particular, we show that the tim...

BACKGROUND The four-herb Chinese medicine PHY906(KD018) has been shown to both enhance the in vivo antitumor activity of irinotecan (CPT-11) against colon cancer tumor allografts and alleviate intestinal toxicity caused by CPT-11. METHODS Since intestinal bacteria can metabolize CPT-11 and PHY906, we investigated whether intestinal bacteria play a critical role in the in vivo activity of PHY9...

BACKGROUND The purpose of the present study was to continue the investigation of the membrane transport mechanisms of 20-(S)-camptothecin (CPT) in order to understand the possible role of membrane transporters on its oral bioavailability and disposition. METHODS The intestinal transport kinetics of CPT were characterized using Caco-2 cells, MDCKII wild-type cells and MDCKII cells transfected ...

This paper undertakes liquefaction analysis with simplified procedures standard penetration test (SPT) data and cone (CPT) obtained from an offshore wind farm in the Changhua area. The soil resistance calculated by SPT-based procedure suggested Japan Railway Association was agreement laboratory results. CPT is widely used site investigation of farms. However, Taiwan’s registered professional en...

Patients treated with high doses of CPT-11 rapidly develop a cholinergic syndrome that can be alleviated by atropine. Although CPT-11 was not a substrate for acetylcholinesterase (AcChE), in vitro assays confirmed that CPT-11 inhibited both human and electric eel AcChE with apparent Kis of 415 and 194 nM, respectively. In contrast, human or equine butyrylcholinesterase (BuChE) converted CPT-11 ...

Camptothecin or CPT and its analogs appear to employ anticancer action by poisoning topoisomerase I (topo I) enzyme. As a result topo I activity inhibited and have established important role against a wide range of tumors. CPT was extracted from bark of Chinese plant Camptotheca acuminate but now a large number of synthetic and semi-synthetics are identified. After activity, researchers organiz...

In Camptotheca acuminata, we studied the cellular sites of accumulation of the alkaloid camptothecin (CPT), in both plants grown in the field and those grown in a greenhouse, subjecting the latter to stress (i.e., draught, nutritional deficit, and pruning). Fresh sections of the leaf, stem, and root were analysed for the presence of CPT by examining the autofluorescence that the CPT molecule em...

The feasibility of placing bounds on CPT violation from experiments with neutral-B mesons is examined. We consider situations with uncorrelated mesons and ones with either unboosted or boosted correlated mesons. Analytical expressions valid for small Tand CPT-violating parameters are presented for time-dependent and time-integrated decay rates, and various relevant asymmetries are derived. We u...

In this talk, we investigate extrinsic CPT violation in neutrino oscillations in matter with three flavors. Note that extrinsic CPT violation is different from intrinsic CPT violation. Extrinsic CPT violation is one way of quantifying matter effects, whereas intrinsic CPT violation would mean that the CPT invariance theorem is not valid. We present analytical formulas for the extrinsic CPT prob...