The mode of binding of myosin subfragment-1 (S1) to actin is known to depend on their molar ratio: when actin is in excess, S1 binds to two actin monomers within the actin filament, and when S1 is in excess or is equimolar with actin, each S1 binds to one actin monomer. Since in vertebrate striated muscle actin is in molar excess over myosin, we expect that in fibers each myosin head binds to t...

We set S1 = R/2πZ throughout. Let (M,ω) be a symplectic manifold. A symplectic S1-action on (M,ω) is a smooth family ψt ∈ Symp(M,ω), t ∈ S1, such that ψt+s = ψt ◦ ψs for any t, s ∈ S1. One can easily check that the corresponding vector fields Xt ≡ d dtψt ◦ψ −1 t is time-independent, i.e., Xt = X is constant in t. We call X the associated vector field of the given symplectic S1-action. Note that...

Content General methods .............................................................................................................................................. S1 Apparatus ......................................................................................................................................................... S2 Abbreviations..................................................

We have analyzed the genetic basis for T cell recognition of an endogenous major histocompatibility complex class II-restricted self peptide. Transgenic mice expressing the influenza virus PR8 hemagglutinin I-Ed-restricted determinant S1 (HA Tg mice) mediate negative selection of PR8 S1-specific T cells, but respond to immunization with a virus containing a closely related analogue, S1(K113). S...

Bordetella pertussis is a gram negative bacterium that causes respiratory tract infection in human (whooping cough). Pertussis toxin (PT) is the main component of current acellular pertussis vaccine and the S1 (subunit1) is the main immunogenic part of it. Thus, S1 has been the target of many studies as a potent candidate of acellular vaccine against Bordetella pertussis, lacking the side effec...