نتایج جستجو برای: نسبت igf
تعداد نتایج: 174480 فیلتر نتایج به سال:
The insulin-like growth factors (IGF-I and IGF-II) and the IGF-I receptor are critically important for normal growth and development of the organism. Gene-deletion of these elements has demonstrated that IGF-I is important for both prenatal and postnatal development, whereas IGF-II is important during prenatal stages only. The IGF-I receptor gene-deleted mouse dies at birth apparently as a resu...
Prostate cancer is the second major cause of male deaths. Obesity, type 2 diabetes, and risk are linked. Insulin-like growth factor II (IGF-II) involved in numerous cellular events, including proliferation survival. The IGF-II gene shares its locus with lncRNA, H19. IGF-II/H19 was first to be identified as being “imprinted”—where paternal copy not transcribed—a silencing phenomenon lost many ty...
PURPOSE The aim of this study was to characterize the relationship of insulin-like growth factor (IGF)-II expression with IGF-I, IGF-I receptor (IGF-IR), cyclooxygenase-2 (COX-2), and matrix metalloproteinase (MMP)-7 in early colorectal carcinogenesis. EXPERIMENTAL DESIGN With the semiquantitative reverse transcriptase-PCR, 90 human colorectal tumor tissues (63 adenomas and 27 submucosal pT1 ...
هورمون رشد و عامل رشد شبه انسولینی 1، از هورمون های آنابولیک هستند که نقش حیاتی در بالیدگی دستگاه های مختلف بدنی به ویژه در کودکی و نوجوانی دارند. ورزش یکی از محرک هایی است که ترشحgh و igf-1 را تحت تأثیر قرار می دهد، امروزه ورزش های آبی به علت ایجاد نشاط در کودکان، بسیار توصیه شده است. هدف این پژوهش بررسی اثر یک دورة 8 هفته ای تمرین در آب بر سطوح استراحتی ghو igf-1 کودکان 9 تا 11 سال پسر است. 1...
Using affinity cross-linking techniques, we report the presence of type I IGF and type II IGF receptors in Madin-Darby canine kidney cells, a line of cells lacking insulin receptors. The IGF receptors were further characterized by competition binding studies and found to be similar to IGF receptors in other tissue types. In Madin-Darby canine kidney cells, the type I IGF receptor binds IGF-I gr...
مقدمه: نقش رسپتورهای تیروزین کینازی در پاتوژنز سرطان کولون در رده های سلول سرطانی و نمونه های توموری متعددی ارزیابی شده است. از بین آنها افزایش بیان رسپتور igf-1r مرتبط با پیش آگهی بد، ترانسفورماسیون، متاستاز، آنژیوژنز و مقاومت به درمانهای رایج در سرطان کولون است. وقتی sirna ضد igf-1r با یک رادیوایزوتوپ همراه می گردد، sirna فرایند rnai را در سلولهاد القاء کرده و خاموش سازی ژن مورد نظر انجام می ...
PURPOSE Growth factors, particularly insulin-like growth factor I (IGF-I) and IGF-I receptor (IGF-IR) in some nonendocrine and a few endocrine tumors, are thought important in recurrence, growth, and aggressiveness. Whether this is true of neuroendocrine tumors such as gastrinomas is unclear. The aim of this study was to address this question in gastrinomas. EXPERIMENTAL DESIGN IGF-I and IGF-...
Downlo type 1 insulin-like growth factor receptor (IGF-1R) is a transmembrane glycoprotein composed of two ellular α subunits and two β subunits with tyrosine kinase activity. The IGF-1R is frequently upregulated cers and signals from the cell surface to promote proliferation and cell survival. Recent attention has d on the IGF-1R as a target for cancer treatment. Here, we report that the nucle...
BACKGROUND Alterations in the PI3K/Akt pathway are found in a wide range of cancers and the development of PI3K inhibitors represents a promising approach to cancer therapy. Constitutive PI3K activation, reflecting an intrinsic oncogenic deregulation of primary blast cells, is detected in 50% of patients with acute myeloid leukemia. However, the mechanisms leading to this activation are current...
Elevated expression of insulin-like growth factor-II (IGF-II) is frequently observed in a variety of human malignancies, including breast, colon, and liver cancer. As IGF-II can deliver a mitogenic signal through both IGF-IR and an alternately spliced form of the insulin receptor (IR-A), neutralizing the biological activity of this growth factor directly is a potential alternative option to IGF...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید