a r t i c l e i n f o JEL classification: C53 G17 Keywords: GARCH Higher conditional moments Approximate predictive distributions Value-at-Risk S&P 500 Treasury bill rate Euro–US dollar exchange rate It is widely accepted that some of the most accurate Value-at-Risk (VaR) estimates are based on an appropriately specified GARCH process. But when the forecast horizon is greater than the frequency...

The O-Ring theory is used to analyze the emergence of ̄rms organized as partnerships. The owner-managers of such entrepreneurial ̄rms bene ̄t from ability matching within their production teams. However, they must bear the project risk. Risk-aversion then induces a second-best solution. Integrated ̄rms managed on behalf of riskneutral residual-claimants face information and/or enforcement problem...

Splenic B-2 cells can be divided into two major subsets: follicular (FO) and marginal zone (MZ) B cells. FO and MZ B cells are generated from immature transitional B cells. Few transcription factors have been identified that regulate FO B cell differentiation. The highly related proteins PU.1, Spi-B, and Spi-C are transcription factors of the E26-transformation-specific family and are important...

The following are highlights from the new series, Circulation: Cardiovascular Quality and Outcomes Topic Review. This series will summarize the most important manuscripts, as selected by the Editor, that have published in the Circulation portfolio. The objective of this new series is to provide our readership with a timely, comprehensive selection of important papers that are relevant to the qu...

Over-expression of MDR1 confers multidrug resistance (MDR) in cancers and remains a major cause for the failure of chemotherapy. In the present study, we found that V-Ets erythroblastosis virus E26 oncogene homolog 2 (ETS2) could activate MDR1 transcription and P-glycoprotein (P-gp) expression in SGC7901 cells. Knockdown of ETS2 attenuated MDR1 transcription and P-gp expression, and increased t...

Bu çalışmada, sol-jel spin kaplama yöntemi kullanılarak mikroskop cam altlıklar üzerine TiO2, TiO2/CoPc ve CoPc filmleri hazırlanmış katkı konsantrasyonunun filmlerin optik yapısal özellikleri etkisi araştırılmıştır. İnce geçirgenliğini ölçmek için 300-1100 nm dalgaboyu aralığında bir spektrofotometre kullanılmıştır. Uv-Vis çalışmaları, B Q bandı absorpsiyon bölgelerine karşılık gelen aralıklar...