Multimodal interaction is employed in a variety of contemporary information systems in order to enhance the flexibility and naturalness of the user interface. In this paper, we propose a comprehensive framework which allows the modeling and specification of multimodal interactions. To this end, we employ an extended notion of ‘dialogue acts’ which can be performed by linguistic or non-linguisti...

OBJECTIVE The aim of the current study is to investigate structural changes on brain MRI using voxel based morphometry (VBM) related to an eight-week mindfulness based intervention (MBI) in Parkinson's Disease (PD). METHODS A total of 27 out of 30 PD patients completed a randomized controlled longitudinal trial. Fourteen patients participated in a structured eight-week program of MBI. Thirtee...

A framework is presented for generalized minimum distance (GMD) decoding with a limited number of decoding trials and a restricted set of reliability values. In GMD decoding, symbols received from the channel may be erased before being fed into an algebraic error-erasure decoder for error correction, in subsequent or simultaneous trials with different erasing patterns. The decision whether or n...

Elevated glucocorticoid (GC) levels are hypothesized to be deleterious to some brain regions, including white matter (WM). Older age is accompanied by increased between-participant variation in GC levels, yet relationships between WM integrity and cortisol levels in older humans are underexplored. Moreover, it is unclear whether GC-WM associations might be general or pathway specific. We analyz...

Towards the development of a methicillin-resistant Staphylococcus aureus (MRSA) vaccine we evaluated a neutralizing anti-glucosaminidase (Gmd) monoclonal antibody (1C11) in a murine model of implant-associated osteomyelitis, and compared its effects on LAC USA300 MRSA versus a placebo and a Gmd-deficient isogenic strain (ΔGmd). 1C11 significantly reduced infection severity, as determined by bio...

Obesity is known to affect the brain's gray matter (GM) and white matter (WM) structure but the interrelationship of such changes remains unclear. Here we used T1-weighted magnetic resonance imaging (MRI) in combination with voxel-based morphometry (VBM) and diffusion-tensor imaging (DTI) with tract-based spatial statistics (TBSS) to assess the relationship between obesity-associated alteration...