Nonlinearity is ubiquitous in physical phenomena. Fluid and plasma mechanics, gas dynamics, elasticity, relativity, chemical reactions, combustion, ecology, biomechanics, and many, many other phenomena are all governed by inherently nonlinear equations. (The one notable exception is quantum mechanics, which is a fundamentally linear theory. Recent attempts at grand unification of all fundamenta...

Human papillomaviruses (HPV) are the main etiological factor for cervical carcinoma. HPV-16 is the most prevalent high-risk HPV-genotype found in HPV-associated cancers. We studied the effect of HPV-16 E7 oncoprotein on cadherin-mediated cell adhesion. The expression of E7 strongly suppressed the cadherin-mediated cell adhesion in the rat fibroblast cell line 3Y1. This suppression was associate...

Background: End-stage renal disease (ESRD) patients have poor health-related quality of life (HRQOL) comparing to general population and comparable HRQOL to patients with other major chronic diseases. Poor HRQOL is associated with shorter survival. There is a limited threshold to which dialysis dose and parameters management can improve HRQOL in ESRD patients. Numerous studies have sought to fi...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 207 No. 4 549–567 www.jcb.org/cgi/doi/10.1083/jcb.201404001 JCB 549 *Mohammed I. Ahmed and Majid Alam contributed equally to this paper. Correspondence to Natalia V. Botchkareva: [email protected] Abbreviations used in this paper: BIO, 6-bromoindirubin-3-oxime; Dox, doxycycline; DTG, double transgenic K14-rtTA/miR-214-TRE; E...

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The use of facial prostheses such as wax ears has been reported in ancient Egypt. The first historically documented evidence comes from sixteenth century, when the French surgeon Ambroise Paré describes the first nose prostheses from gold, silver and “papier mâché”, which were held to the face by a string tied around the head. In late 19th century Claude Martin conceived an idea of an immediate...