نتایج جستجو برای: منطقه 5

تعداد نتایج: 1269184  

Journal: :Chemical research in toxicology 2000
C J La Francois Y H Jang T Cagin W A Goddard L C Sowers

Emerging data strongly suggest that the oxidation of DNA bases can contribute to genomic instability. Structural changes to DNA, induced by base oxidation, may reduce the fidelity of DNA replication and interfere with sequence-specific DNA-protein interactions. We have examined the structures of a series of pyrimidine deoxynucleoside oxidation damage products in aqueous solution. The modified n...

ژورنال: :جغرافیا و مطالعات محیطی 2014
رضا ویسی علیرضا دانش نظافت مریم محمدی

با گسترده تر شدن شهر تهران و متمرکز شدن فضای داخلی آن خلاء ضرورت دسترسی به محیطهای طبیعی و سبز بیشتر نمایان شده است. اهداف این پژوهش بررسی میزان سازگاری پارک های محله ای منطقه 5 شهرداری تهران با کاربری های همجوار، تحلیل میزان تناسب آنها با استانداردهای موجود، بررسی عوامل موثر در کاهش تناسب پارک های محله ای و مکان یابی اراضی متناسب با استقرار پارک های مذکور در منطقه مورد مطالعه می باشد. در این پ...

2014
Zachary L. Wescoe Jacob Schreiber Mark Akeson

Individual DNA molecules can be read at single nucleotide precision using nanopores coupled to processive enzymes. Discrimination among the four canonical bases has been achieved, as has discrimination among cytosine, 5-methylcytosine (mC), and 5-hydroxymethylcytosine (hmC). Two additional modified cytosine bases, 5-carboxylcytosine (caC) and 5-formylcytosine (fC), are produced during enzymatic...

2016
Eerappa Rajakumara Naveen Kumar Nakarakanti M. Angel Nivya Mutyala Satish

5-Methylcytosine (5 mC) is associated with epigenetic gene silencing in mammals and plants. 5 mC is consecutively oxidized to 5-hydroxymethylcytosine (5 hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) by ten-eleven translocation enzymes. We performed binding and structural studies to investigate the molecular basis of the recognition of the 5 mC oxidation derivatives in the context o...

2016
Daniel J. Crawford Monica Yun Liu Christopher S. Nabel Xing-Jun Cao Benjamin A. Garcia Rahul M. Kohli

Modification of cytosine-guanine dinucleotides (CpGs) is a key part of mammalian epigenetic regulation and helps shape cellular identity. Tet enzymes catalyze stepwise oxidation of 5-methylcytosine (mC) in CpGs to 5-hydroxymethylcytosine (hmC), or onward to 5-formylcytosine (fC) or 5-carboxylcytosine (caC). The multiple mC oxidation products, while intricately linked, are postulated to play ind...

Journal: :Angewandte Chemie 2016
Huihua Sun Wan Lin Yeo Yee Hwee Lim Xinying Chew Derek John Smith Bo Xue Kok Ping Chan Robert C Robinson Edward G Robins Huimin Zhao Ee Lui Ang

Fluorinases offer an environmentally friendly alternative for selective fluorination under mild conditions. However, their diversity is limited in nature and they have yet to be engineered through directed evolution. Herein, we report the directed evolution of the fluorinase FlA1 for improved conversion of the non-native substrate 5'-chloro-5'-deoxyadenosine (5'-ClDA) into 5'-fluoro-5'-deoxyade...

Journal: :امداد و نجات 0
مهراب شریفی سده m sharifi sadeh

0

Journal: :Biomolecular concepts 2012
Nathalie Véron

Abstract Dynamic DNA methylation is a prerequisite for many developmental processes and maintenance of cellular integrity. In mammals however, mechanisms of active DNA demethylation have for long been elusive. The discovery of the ten-eleven translocation (Tet) family of enzymes that oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) or 5-carboxylcytosine (...

2017
Ashley H. Ramsawhook Lara C. Lewis Maria Eleftheriou Abdulkadir Abakir Paulina Durczak Robert Markus Seema Rajani Nicholas R.F. Hannan Beth Coyle Alexey Ruzov

For several decades, 5-methylcytosine (5mC) has been thought to be the only DNA modification with a functional significance in metazoans. The discovery of enzymatic oxidation of 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) as well as detection of N6-methyladenine (6mA) in the DNA of multicellular organisms provided additional degrees of complexity ...

2015
Daniel Gackowski Ewelina Zarakowska Marta Starczak Martyna Modrzejewska Ryszard Olinski Wendy Dean

BACKGROUND Replication-independent active/enzymatic demethylation may be an important process in the functioning of somatic cells. The most plausible mechanisms of active 5-methylcytosine demethylation, leading to activation of previously silenced genes, involve ten-eleven translocation (TET) proteins that participate in oxidation of 5-methylcytosine to 5-hydroxymethylcytosine which can be furt...

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