نتایج جستجو برای: مسیر ras

تعداد نتایج: 54191  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه زابل - دانشکده کشاورزی 1390

وقوع سیلاب های مخرب در دشت های سیلابی خسارت های فراوانی را به دنبال داشته است بطوریکه لزوم پیش بینی رفتار هیدرولیکی رودخانه ها در برقراری توسعه مناسب این مناطق از اهمیت ویژه ای برخوردار می باشد. سرریز زهک – نیاتک در راستای کاهش خطرات سرریز جریان رودخانه سیستان و همچنین افزایش پتانسیل آبگیری از رودخانه هیرمند به میزان 2200 مترمکعب بر ثانیه در شرایط سیلابی، طراحی و اجرا گردید. گذشت نزدیک به یک ده...

2006
Huibin Yang Raymond R. Mattingly

The Ras-GRF1 exchange factor has regulated guanine nucleotide exchange factor (GEF) activity for H-Ras and Rac1 through separate domains. Both H-Ras and Rac1 activation have been linked to synaptic plasticity, and thus could contribute to the function of Ras-GRF1 in neuronal signal transduction pathways that underlie learning and memory. We defined the effects of RasGRF1 and truncation mutants ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Jason G Williams Kamesh Pappu Sharon L Campbell

Ras is a guanine nucleotide-binding protein that cycles between inactive GDP-bound and active GTP-bound states to regulate a diverse array of cellular processes, including cell growth, apoptosis, and differentiation. The guanine nucleotide-bound state of Ras is tightly maintained by regulatory factors to promote regulated growth control. A class of regulatory molecules that lead to Ras activati...

Journal: :Molecular biology of the cell 2005
Stephen P Holly Mark K Larson Leslie V Parise

The Ras family GTPase, R-Ras, elicits important integrin-dependent cellular behaviors such as adhesion, spreading and migration. While oncogenic Ras GTPases and R-Ras share extensive sequence homology, R-Ras induces a distinct set of cellular behaviors. To explore the structural basis for these differences, we asked whether the unique N-terminal 26 amino acid extension of R-Ras was responsible ...

2017
MaKendra Umstead Jinglin Xiong Qi Qi Yuhong Du Haian Fu

In cancer, upregulated Ras promotes cellular transformation and proliferation in part through activation of oncogenic Ras-MAPK signaling. While directly inhibiting Ras has proven challenging, new insights into Ras regulation through protein-protein interactions may offer unique opportunities for therapeutic intervention. Here we report the identification and validation of Aurora kinase A (Auror...

Ali Pedarzadeh, Aryan Naghedi Fahimeh Dorri Mashhadi Fatemeh Safari*, Fereshteh Safari, Javad Zavvar Reza Tahmineh Hashemizadeh,

Background and objectives: Resveratrol(3,5,4′-trihydroxy-trans-stilbene) is a natural polyphenole phytoalexin which exerts potential cardioprotective effects, but the cellular and molecular mechanisms responsible for these effects are still unknown. Cardiac renin angiotensin system (RAS) over-activation plays an important role in pathogenesis of left ventricula...

نیاز به برنامه ­ریزی منطقه­ای در سال­های اخیر در جهان و ایران مورد توجه پژوهشگران و سیاست­گذاران اقتصادی واقع شده است. از این رو، روش­های مختلفی برای استفاده از آمار و داده­های منطقه­ای توسط پژوهشگران و اندیشمندان پیشنهاد شده است؛ اما به دلیل کم سابقه­تر بودن این نوع برنامه­ریزی و داده­های متفاوت هر کشور، استفاده از روش­های برنامه­ریزی منطقه­ای یک کشور برای سایر کشورها، نیاز به تعدیل مناسب با د...

2013
Stephen J. Lynch Jiri Zavadil Angel Pellicer

It has been recently shown that N-ras plays a preferential role in immune cell development and function; specifically: N-ras, but not H-ras or K-ras, could be activated at and signal from the Golgi membrane of immune cells following a low level T-cell receptor stimulus. The goal of our studies was to test the hypothesis that N-ras and H-ras played distinct roles in immune cells at the level of ...

Journal: :Cell 1998
Derek S Sieburth Qun Sun Min Han

We describe the identification and characterization of a novel gene, sur-8, that positively regulates Ras-mediated signal transduction during C. elegans vulval development. Reduction of sur-8 function suppresses an activated ras mutation and dramatically enhances phenotypes of mpk-1 MAP kinase and ksr-1 mutations, while increase of sur-8 dosage enhances an activated ras mutation. sur-8 appears ...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005
Arvind Singh A Pavani Sowjanya Gayatri Ramakrishna

The cellular Ras is known to play an important role in cellular proliferation mediated by growth factor receptor. Evidence also points to its role in growth arrest. Substantiated proof for growth-suppressive activity of wild-type Ras comes from studies that showed 1) loss of wild-type ras allele in tumors, 2) suppression of growth in cells transformed by oncogenic ras upon overexpression of wil...

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