Polycythemia vera (PV) treatment with interferon α (IFNα) is frequently limited by dose-related toxicity. PV CD34(+) cells are characterized by overexpression of Bcl-xL, which can be antagonized by ABT-737 leading to apoptosis. We explored the effects of ABT-737 and IFNα on PV hematopoiesis. Both IFNα and ABT-737 alone or in combination had a modest effect on normal hematopoiesis but each indiv...

Familial clustering of malignancies provides a unique opportunity to identify molecular causes of cancer. Polycythemia vera (PV) is a myeloproliferative disorder due to an unknown somatic stem cell defect that leads to clonal myeloid hyperproliferation. We studied 6 families with PV. The familial predisposition to PV appears to follow an autosomal dominant inheritance pattern with incomplete pe...

Stimulus processing in fear conditioning is constrained by parvalbumin interneurons (PV-INs) through inhibition of principal excitatory neurons. However, the contributions of PV-IN microcircuits to input gating and long-term plasticity in the fear system remain unknown. Here we interrogate synaptic connections between afferent pathways, PV-INs, and principal excitatory neurons in the basolatera...

The molecular features of Pseudomonas syringae pv. actinidiae strains isolated in Korea were compared with strains isolated in Japan and Italy. Sequencing of eight P. syringae pv. actinidiae and three P. syringae pv. theae strains revealed a total of 44 single nucleotide polymorphisms across 4,818 bp of the concatenated alignment of nine genes. A multiplex PCR assay was developed for the detect...

Abstract: This paper provides a review on various PV simulator technologies as well as presents a novel equivalent photovoltaic (PV) source that was constructed by using un-illuminated solar panels and a DC power supply that operates in current source mode. The constructed PV source was used for testing photovoltaic converters and various maximum power point tracking (MPPT) algorithms required ...

Polycythemia vera (PV) is a myeloproliferative disorder associated with neurologic sequelae. The most severe neurologic processes affecting patients with PV are thrombotic and hemorrhagic strokes. Few cases published in the medical literature describe developments of other neurologic symptoms, including papilledema, oculomotor nerve palsy, one-and-a-half syndrome, and trochlear nerve syndrome, ...

Photovoltaic systems are attractive renewable energy sources for Thailand because of high daily solar irradiation, about 18 MJ/m2/day. Furthermore, renewable energy is boosted by the government incentive on adders on electricity from renewable energy like solar PV, wind and biomass, introduced in the second half of 2000s. For PV systems, domestic rooftop PV units, commercial rooftop PV units an...

BACKGROUND AND OBJECTIVES Percutaneous portal vein (PV) stent placement is used to manage PV occlusion or stenosis caused by malignancy. The use of endoscopic ultrasonography (EUS) has expanded to include vascular interventions. The aim of this study was to examine the technical feasibility and safety of EUS-guided transhepatic PV stent placement in a live porcine model. MATERIALS AND METHODS...

This paper presents a new system configuration for a large-scale Photovoltaic (PV) power system with multi-line transmission/distribution networks. A PV power plant is reconfigured in a way that two adjacent power system networks/ feeders can be interconnected. The inverter modules in a PV power plant are configured such that the system is represented as a back to back inverter connected multi-...