Gene fission can convert monomeric proteins into two-piece catalysts, reporters, and transcription factors for systems and synthetic biology. However, some proteins can be challenging to fragment without disrupting function, such as near-infrared fluorescent protein (IFP). We describe a directed evolution strategy that can overcome this challenge by randomly fragmenting proteins and concomitant...

RATIONALE The tumor microenvironment (TME) is heterogeneous including both malignant and host cell components as well as regions of hypoxia, elevated interstitial fluid pressure (IFP) and poor nutrient supply. The quantitative extent to which the microenvironmental properties of primary tumors are recapitulated in xenograft models is not well characterized. METHODS Xenografts were generated b...

Disentanglement is a highly desirable property of representation owing to its similarity human understanding and reasoning. Many works achieve disentanglement upon information bottlenecks (IB). Despite their elegant mathematical foundations, the IB branch usually exhibits lower performance. In order provide an insight into problem, we develop annealing test calculate freezing point (IFP), which...

In this paper, we prove several supercongruences conjectured by Z.-W. Sun ten years ago via certain strange hypergeometric identities. For example, for any prime p>3, show that∑k=0p−1(4k2k+1)(2kk)48k≡0(modp2), and∑k=0p−1(2kk)(3kk)24k≡{((2p−2)/3(p−1)/3)(modp2)ifp≡1(mod3),p/((2p+2)/3(p+1)/3)(modp2)ifp≡2(mod3). We also obtain some other results of such types.

A 70-year-old woman visited our hospital complaining of anemia. Laboratory testing revealed a peripheral blood hemoglobin concentration of 9.4g/dL. Upper and lower gastrointestinal endoscopic examinations were performed to investigate the cause of the anemia. The findings of the upper endoscopic examination were normal. However, the lower endoscopic examination revealed a semipedunculated polyp...

Two growth assays and one nitrogen balance experiment were conducted to develop an ideal amino acid pattern for 10-kg pigs. Crossbred pigs were fed chemically defined amino acid diets containing four indispensable amino acid (AA) patterns: 1) the Illinois final amino acid pattern (IFP), a recently developed AA profile for purified diets; 2) the Illinois ideal amino acid pattern (IIP), a modific...

Integrated fruit production (IFP) offers an alternative to the chemically intensive, conventional pear production system. In 1994, we began a 4-year project supported by the Hood River Grower Shipper Association (HRGSA) together with Oregon's Center for Applied Agricultural Research (CAAR) to demonstrate to the industry how to bring about changes in orchard management practices, particularly as...

Stochastic Joint Simulation of Facies and Diagenesis: A Case Study on Early Diagenesis of the Madison Formation (Wyoming, USA) — The aim of this paper is to propose an integrated approach to reproduce both facies and diagenetic trends in a static reservoir model based on an outcrop Oil & Gas Science and Technology – Rev. IFP Energies nouvelles, Vol. 67 (2012), No. 1, pp. 123-145 Copyright © 201...

PURPOSE To quantify the radiobiological advantages obtained by an Improved Forward Planning technique (IFP) and two IMRT techniques using different fractionation schemes for the irradiation of head and neck tumours. The conventional radiation therapy technique (CONVT) was used here as a benchmark. METHODS Seven patients with head and neck tumours were selected for this retrospective planning ...