Air pollutants pose a risk to forest health and vitality in the United States. Here we present the major findings from a national scale air pollution assessment that is part of the United States' 2003 Report on Sustainable Forests. We examine trends and the percent forest subjected to specific levels of ozone and wet deposition of sulfate, nitrate, and ammonium. Results are reported by Resource...

Replication protein A (RPA), a heterotrimer with subunits of molecular masses 70, 32, and 14 kDa, is a single-stranded-DNA-binding factor involved in DNA replication, repair, and recombination. There have been only three reported cases of anti-RPA in systemic lupus erythematosus (SLE) and Sjögren syndrome (SjS). This study sought to clarify the clinical significance of autoantibodies against RP...

Existing licensed anthrax vaccines are administered parenterally and require multiple doses to induce protective immunity. This requires trained personnel and is not the optimum route for stimulating a mucosal immune response. Microencapsulation of vaccine antigens offers a number of advantages over traditional vaccine formulations, including stability without refrigeration and the potential fo...

Improved access to effective tests for diagnosing tuberculosis (TB) has been designated a public health priority by the World Health Organisation. In high burden TB countries nucleic acid based TB tests have been restricted to centralised laboratories and specialised research settings. Requirements such as a constant electrical supply, air conditioning and skilled, computer literate operators p...

that this phosphorylation event may contribute to the inhibition of DNA replication activity (12, 13). These studies, in conjunction with the observation that cell lines derived from AT patients lack the irradiation-induced S-phase arrest (i.e., exhibit RDS; Refs. 22 and 23) and are deficient in IR-induced RPA phosphorylation (13, 14), sug gested that RPA phosphorylation may play a functional r...

The particle-particle random phase approximation (pp-RPA) is a promising method for studying charge transfer(CT) excitations. Through a detailed analysis on two-electron deficient systems, we show that the pp-RPA is always able to recover the long-distance asymptotic -1/R trend for CT excitations as a result of the concerted effect between orbital energies and the pp-RPA kernel. We also provide...

BACKGROUND Editing deaminases have a pivotal role in cellular physiology. A notable member of this superfamily, APOBEC3G (A3G), restricts retroviruses, and Activation Induced Deaminase (AID) generates antibody diversity by localized deamination of cytosines in DNA. Unconstrained deaminase activity can cause genome-wide mutagenesis and cancer. The mechanisms that protect the genomic DNA from the...

A potentially serious but rare complication of mediastinoscopy procedures is acute damage to any of the great vessels in the region of the distal trachea and carina. We report a case of serious hemorrhage from a mediastinoscopic biopsy-injury to the posterior aspects of the right pulmonary artery (RPA), which required sternotomy, cardiopulmonary bypass, division and retraction of the ascending ...

We discuss novel features of a new continuum RPA formulated in the coordinate-space Hartree-Fock-Bogoliubov framework. This continuum quasiparticle RPA takes into account both the oneand two-particle escaping channels. The theory is tested with numerical calculations for monopole, dipole and quadrupole excitations in neutron-rich oxygen isotopes near the drip-line. Effects of the particle-parti...

BACKGROUND The detection of Mycobacterium avium subsp. paratuberculosis (MAP) infections in ruminants is crucial to control spread among animals and to humans. Cultivation of MAP is seen as the gold standard for detection, although it is very time consuming and labour intensive. In addition, several PCR assays have been developed to detect MAP in around 90 minutes, but these assays required hig...