Benzo[a]pyrene (BP) is mutagenic but noncarcinogenic in the murine colon. Recently, we reported rapid induction of colonic tumors by treatment of CD2F1 mice with BP (125 mg/kg for 5 days) followed by a colitis inducer, dextran sulfate sodium (DSS) (4% in drinking water for 1 or 2 weeks). However, there are no reports on detailed time course and histopathological features of colonic proliferativ...

The present study aimed to determine whether there is an association between abnormalities in enteroendocrine cells in dextran sulfate sodium (DSS)‑induced colitis and the clonogenic and/or proliferative activities of stem cells. A total of 48 male Wistar rats were divided into four groups. Animals in the control group were provided with normal drinking water, whereas DSS colitis was induced in...

The Semantic Web shares many goals with Decision Support Systems (DSS), e.g., being able to precisely interpret information, in order to deliver relevant, reliable and accurate information to a user when and where it is needed. DSS have in addition more specific goals, since the information need is targeted towards making a particular decision, e.g., making a plan or reacting to a certain situa...

Exposure to dextran sulphate sodium (DSS) induces acute colitis, which is normally resolved after DSS removal. To study chronicity, mice are typically subjected to 3-5 cycles of weekly DSS-exposures, each followed by resting period of 1-2 weeks. Herein, we describe a novel and convenient way of inducing chronic, progressive colitis by a single exposure to DSS. C57BL/6 mice exposed to DSS for 5 ...

BACKGROUND/AIMS Impaired colonocyte metabolism of butyrate has been implicated in the aetiopathogenesis of ulcerative colitis. Colonocyte butyrate metabolism was investigated in experimental colitis in mice. METHODS Colitis was induced in Swiss outbred white mice by oral administration of 4% dextran sulphate sodium (DSS). Colonocytes isolated from colitic and normal control mice were incubate...

BACKGROUND AND AIMS The effects of dextran sulphate sodium (DSS) on mouse intestinal epithelial cells and intraepithelial lymphocytes were analysed to investigate the mechanism by which DSS induces colitis and tumours in mice. Cytotoxicity of DSS towards intestinal epithelial cells and intestinal intraepithelial lymphocyte hybridomas or fresh intestinal intraepithelial lymphocytes seems to have...

This paper reports and discusses the results of a survey conducted among experts working in the field of decision support systems (DSS) in Australian agriculture. It also reviews the literature on DSS in the light of these experts’ responses. The findings from this survey have consolidated our understanding of the current state of DSS in Australian agriculture. The uptake of DSS by farmers has ...

Essential hypertension is a complex trait influenced by multiple genes known as quantitative trait loci (QTLs) for blood pressure (BP). It is not clear, however, what roles these QTLs play in maintaining normotension. Insights gained toward the maintenance of normotension will shed light on how hypertension can result from a deficiency or malfunctioning of this maintenance. Currently, congenic ...

JBP485 (cyclo-trans-4-L-hydroxyprolyl-L-serine), a dipeptide first isolated from Laennec that is a proprietary product made from the hydrolysate of human placenta, has been reported to have several biological properties, such as anti-hepatotoxic, anti-inflammatory and anti-apoptotic activities. However, the effect of JBP485 on inflammatory bowel disease has not yet been reported. Here we invest...

A human user is centrally involved in a Decision Support System (DSS) task, whereas for an autonomous agent system, a user’s role is a more abstract notion of oversight and approval. In this paper, we examine the potential integration of a multi-agent architecture into a DSS. The motivation in this work is to utilise autonomous agent problemsolvers within a suitable multi-agent framework in suc...