Domoic acid (DA), a neurotoxin, is produced by marine algae and has caused toxications worldwide in animals and humans. However, the toxicokinetics of DA have not been fully evaluated, and information is missing on the disposition of DA following oral exposures at doses that are considered safe for human consumption. In this study, toxicokinetics of DA were investigated in cynomolgus monkeys fo...

Cholinergic transmission in the striatum functions as a key modulator of dopamine (DA) transmission and synaptic plasticity, both of which are required for reward and motor learning. Acetylcholine (ACh) can elicit striatal DA release through activation of nicotinic ACh receptors (nAChRs) on DA axonal projections. However, it remains controversial how muscarinic ACh receptors (mAChRs) modulate s...

The wide variety of calls received by the Hawaii Poison Center are described. These include the typical, humorous and calls unique to the islands. Methods include descriptive anecdotal recall and review of Hawaii Poison Center call statistics. A brief description of staff, resources and call taking procedures are also provided.

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Brazilian physician and researcher Henrique da Rocha Lima was born in 1879 in the city of Rio de Janeiro, where he studied medicine and obtained the degree of M.D. in 1901. He specialized in Clinical Medicine in Germany and was the ambassador in European countries of the scientific medicine that emerged from the Oswaldo Cruz Institute in the early twentieth century. Rocha Lima has discovered th...

Figure 1. Professor Da-Yi Hu, MD, FACC Professor Da-Yi Hu (Figure 1) was born in Henan province of central China, in 1946. He graduated from the Beijing Medical School (now Peking University Health Science Center) in 1970 and furthered his education both at SUNY-Oswego and University of Illinois from 1985 to 1987. Professor Hu has been a pioneer in the field of radio-frequency ablation technolo...

Any product of the creative mind of Professor McMurrich is certain to be valuable and interesting. His profound scholarship and his happy faculty of presenting the most recondite material in intriguing and interesting ways is invariably worthwhile and stimulating. Faced with the problem of evaluating the position of Leonardo da Vinci in the science of Anatomv, he has spent ten years in what mus...

Beam commissioning in the KEK Digital Accelerator, which is a small scale induction synchrotron (IS), has been conducted since the middle of 2011. Longitudinal beam motion in the induction synchrotron, utilizing induction cells (IC) for acceleration and confinement, is characterized as barrier bucket acceleration. A tracking code has been developed to understand the longitudinal motion affected...

The goal of the Portal da Língua Portuguesa project is to construe a set of lexical resources with a double objective. On the one hand, the resources serve as the content source for a web site about the Portuguese language, aimed at the general public. On the other hand, the resources are built to serve as an open source repository of lexical information for linguistic research. The design of t...

Introduction Discriminant function analysis is used to determine which continuous variables discriminate between two or more naturally occurring groups. For example, a researcher may want to investigate which variables discriminate between fruits eaten by (1) primates, (2) birds, or (3) squirrels. For that purpose, the researcher could collect data on numerous fruit characteristics of those spe...