نتایج جستجو برای: مدلسازی اطلاعات ساختمان bim
تعداد نتایج: 126460 فیلتر نتایج به سال:
the management philosophy, namely, customer relationship management (crm) has been widely accepted and successfully applied across a range of sectors. however, there has been very little research efforts in the field of crm in the construction industry. this paper provides a review of the crm philosophy and technology, and considers the implications benefits and challenges to construction organ...
Chimeric somatostatin/dopamine compounds such as BIM-23A760, an sst2/sst5/D2 receptors-agonist, have emerged as promising new approaches to treat pituitary adenomas. However, information on direct in vitro effects of BIM-23A760 in normal and tumoral pituitaries remains incomplete. The objective of this study was to analyze BIM-23A760 effects on functional parameters (Ca2+ signaling, hormone exp...
Building Information Modelling (BIM) offers the possibility of prototyping building design and construction options in a simulated system, before construction begins, offering the potential for improvements in productivity, product quality and sustainability. In addition, the information resulting from the design and construction process can be transferred for use in the ongoing management and ...
Bim, a BH3-only Bcl-2 family member, is required for apoptosis of thymocytes in response to negative selection signals. Regulation of the apoptotic activity of Bim during negative selection is not understood. In this study we demonstrate that in murine thymocytes undergoing apoptosis in response to anti-CD3epsilon injection, levels of Bim protein expression do not change. In immature thymocytes...
A critical hallmark of cancer cell survival is evasion of apoptosis. This is commonly due to overexpression of anti-apoptotic proteins such as Bcl-2, Bcl-X(L), and Mcl-1, which bind to the BH3 α-helical domain of pro-apoptotic proteins such as Bax, Bak, Bad, and Bim, and inhibit their function. We designed a BH3 α-helical mimetic BH3-M6 that binds to Bcl-X(L) and Mcl-1 and prevents their bindin...
BIM is a proapoptotic protein that initiates apoptosis triggered by EGFR tyrosine kinase inhibitors (TKI). mTOR negatively regulates apoptosis and may influence response to EGFR TKI. We examined mRNA expression of BIM and MTOR in 57 patients with EGFR-mutant NSCLC from the EURTAC trial. Risk of mortality and disease progression was lower in patients with high BIM compared with low/intermediate ...
In the context of Architecture, Building Information Modelling (BIM) is a design methodology which enables all of the design details, decisions and characteristics to be held within a collaborative digital representation and information package. The design and project information can then be shared, accessed and altered live, facilitating an efficient and fluid collaborative design and asset ma...
Apoptosis of vascular cells, including pericytes and endothelial cells, contributes to disease pathogenesis in which vascular rarefaction plays a central role. Bim is a proapoptotic protein that modulates not only apoptosis but also cellular functions such as migration and extracellular matrix (ECM) protein expression. Endothelial cells and pericytes each make a unique contribution to vascular ...
The current economic difficulties have affected most practitioners within the industry and, as a result, many firms and contractors are bidding for fewer projects, resulting in below-cost tenders. It is clear that, many firms and contractors are now operating on thin margins; which makes it increasingly difficult for them to commit to the introduction of new software applications and system upg...
The major focus of this paper is to identify the advantages, challenges and usability of BIM during the project life cycle. Understanding the actual advantages of BIM is an essential driver for effective adaptation while both academic research and case studies particularly within construction and post construction stages failed to analyse and quantify BIM benefits. It was also found there is la...
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