Metoclopramide, a dopamine antagonist, stimulates aldosterone secretion in normal man. We studied the response of plasma aldosterone, plasma renin activity, cortisol, sodium, potassium and serum prolactin to a 10-mg intravenous dose of metoclopramide in six dexamethasone suppressed patients with aldosteronism (four with adrenal adenoma, two with bilateral adrenal hyperplasia) and in six dexamet...

OBJECTIVE This study aimed to a) compare the efficacy of metoclopramide and erythromycin in the treatment of feed intolerance in critical illness; and b) determine the effectiveness of "rescue" combination therapy in patients who fail monotherapy. DESIGN Randomized controlled trial. SETTING Level III mixed medical and surgical intensive care unit. PATIENTS Ninety mechanically ventilated, ...

SUMMARY OBJECTIVE: To assess the impact of metoclopramide-induced hyperprolactinemia in cellular death and proliferation harderian gland female mice. METHODS: Twenty mice were divided into two groups 10 animals each treated: 0.2 mL saline solution (controls, Ctr) 200 µg metoclopramide (experimental, hyperprolactinemia), both for 50 consecutive days at 12:00 a.m. On 50th day, euthanized, glands ...

Recently, regulatory agencies in North America and Europe re-evaluated the safety of metoclopramide. This resulted in recommendations and restrictions in order to minimize the risk of neurological and other adverse reactions associated with the use of metoclopramide. The side effects in non-ICU patients are as follows: 1. Neurological adverse reactions, including extrapyramidal disorders, dyski...

We have studied 746 males and females undergoing general anaesthesia for any type of surgical procedure in a double-blind, controlled, randomized study. After experiencing at least one nausea and/or one emetic episode in the 6 h after recovery from anaesthesia, patients received either ondansetron 4 mg i.v. or metoclopramide 10 mg i.v. Patients were observed for postoperative nausea and vomitin...

ALTHOUGH angiotensin, potassium, sodium, and adrenocorticotrophic hormone are generally acknowledged as major direct influences on aldoster-one secretion, there is a strong case for the existence of other factors which affect aldosterone secretion and which may play physiological roles (see Cogh-lan et al., 1979, for review). The plasma aldosterone response to metoclopramide (a dopamine antagon...