Background: In this study, the efficacy of nitazoxanide in the treatment of Helicobacter pylori isolates, which were resistant to metronidazole, was examined.   Methods: One hundred twenty two patients who underwent endoscopy examinations at Kasra and Laleh hospitals in Tehran from November 2014 to July 2015 were enrolled. Helicobacter pylori strains were isolated from the patients&rsqu...

Metronidazole is commonly prescribed and has not been known to cause drug-induced immune thrombocytopenia. We have provided clinical and laboratory evidence with DDabs that metronidazole can cause drug-induced immune thrombocytopenia (DITP). Providers must be aware of metronidazole causing DITP because recognition of thrombocytopenia is critical and cessation of the drug should occur promptly.

A double-blind randomised trial was carried out among 46 patients undergoing elective colonic surgery; 27 patients received prophylactic metronidazole and 19 received placebo. Anaerobic infections did not develop in any of the metronidazole-treated patients, but did develop in 11 (58%) of 19 controls who were subsequently successfully treated with metronidazole.

A prospective study was conducted to compare the efficacy of Metronidazole and Tetracycline in the management of acne rosacea. Ninteen patients took part in the study who had papulo-pustular rosacea. Metronidazole (200 mg twice daily) was found as effective as Tetracycline (250 mg twice daily). No significant side effects of Metronidazole were observed in the eight weeks study (JPMA 35 : 148, 1...

We determined the susceptibilities of five strains of Trichomonas vaginalis, one of which was metronidazole resistant, to 50 antimicrobial agents. For the metronidazole-susceptible strains, the most active agents were metronidazole, tinidazole, mebendazole, furazolidone, and anisomycin. Against the resistant strain mebendazole, furazolidone, and anisomycin were the most active. Antifungal agent...

We report the magnetic resonance imaging (MRI) findings of metronidazole-induced encephalopathy in a 58-year-old man who was treated with metronidazole for hepatic encephalopathy. MRI is likely to be helpful in confirming the diagnosis of metronidazole toxicity in clinically suspected cases.

Metronidazole is associated with numerous neurologic complications, including peripheral neuropathy particularly in patients; those are on high doses of metronidazole for prolonged period. We hereby report a case of liver abscess that developed sensory polyneuropathy following 11 days of metronidazole therapy at low cumulative dose.

OBJECTIVE To evaluate cefuroxime and metronidazole antibiotic prophylaxis. DESIGN Observational nonrandomised 1-year prospective cohort study. SETTING Fifty-three hospitals in Finland. POPULATION A total of 5279 women undergoing hysterectomy for benign indications, with cefuroxime given to 4301 and metronidazole given to 2855. Excluding other antibiotics, cefuroxime alone was given to 201...

We report here the complete genome sequence of a metronidazole-resistant Helicobacter pylori strain (MET(r)). The MET(r) strain was obtained under exposure of H. pylori 26695 on agar plates with low metronidazole concentrations. The genome data provide insight into the genomic changes of H. pylori under selection by metronidazole in vitro.