In der Schweiz sind im Jahr 2020 144 337 von 8 637 000 Menschen – ca. 1,67% Bevölkerung an Demenz erkrankt. Die Inzidenz steigt mit dem Alter, weshalb die Zahl weiter zunehmen wird. Da bisher keine Therapie zur Verhinderung Progression bzw. Heilung existiert, ist Prognose Betroffenen schlecht und fortschreitender Pflegebedürftigkeit assoziiert. Diese Guideline soll Hausärzteschaft helfen, Patie...

Streptococcus pyogenes (group A Streptococcus [GAS]) causes a wide variety of diseases, ranging from mild noninvasive to severe invasive infections. Mutations in regulatory components have been implicated in the switch from colonization to invasive phenotypes. The inactivation of the sil locus, composed of six genes encoding a quorum-sensing complex, gives rise to a highly invasive strain. Howe...

Recent studies revealed a striking morphological change of mitochondria during apoptosis. Mitochondria become fragmented and notably, the fragmentation contributes to mitochondrial outer membrane permeabilization and consequent release of apoptotic factors. In renal tubular cells, mitochondrial fragmentation involves the activation of Drp1, a key mitochondrial fission protein. However, it is un...

Beta,beta-dimethyl acryl shikonin is an extract from the root of plant Arnebia nobilis which has been shown to possess anti-cancer activity. However, its toxicity limited further development of shikonin as a therapeutic agent. Subsequently, several analogues of beta,beta-dimethyl acryl shikonin were synthesized. One of these analogues, shikonin 93/637 was found to be significantly less toxic co...

BACKGROUND The aim of the present study was to investigate the chromosomal abnormalities and to identify the most prevalent or frequent type of chromosomal abnormalities in cases of amenorrhea from the southern region of India. METHODS A total of 637 cases with amenorrhea were analyzed using G- banding, C-banding, Silver staining, and fluorescence in situ hybridization was done wherever neces...

En Suisse, 144 337 personnes sur 8 637 000 – soit environ 1,67% de la population ont présenté une démence en 2020. L’incidence augmente avec l’âge et les chiffres vont donc continuer croître. Comme il n’existe actuellement aucun traitement pour empêcher progression ou mener à guérison, le pronostic des concernées est mauvais associé un besoin croissant soins. Les présentes recommandations but d...