Silymarin from milk thistle (Silybum marianum) plant has been reported to show anti-cancer, anti-inflammatory, antioxidant and hepatoprotective effects. For anti-cancer activity, silymarin is known to regulate cell cycle progression through cyclin D1 downregulation. However, the mechanism of silymarin-mediated cyclin D1 downregulation still remains unanswered. The current study was performed to...

We tested whether rosuvastatin (RST) protected against oxygen-glucose deprivation (OGD)-induced cell death in primary rat cortical neuronal cultures. OGD reduced neuronal viability (%naive controls, mean +/- SE, n = 24-96, P < 0.05) to 44 +/- 1%, but 3-day pretreatment with RST (5 microM) increased survival to 82 +/- 2% (P < 0.05). One-day RST treatment was not protective. RST-induced neuroprot...

OBJECTIVE Identify factors that predict fall-related injury in hospitalized adults. DESIGN Retrospective records review. SETTING 435-bed university hospital. PARTICIPANTS Inpatients with reported falls in 2010. RESULTS Medical records were available for 286/293 (98%) of reported falls in 251 patients. 25% (63/286) of falls were associated with injury, 4% (11/286) with serious injury. Co...

In order to prove that a monoclonal antibody, KJ1-26.1, reacted with the idiotypic portion of the receptor for antigen plus major histocompatibility complex product (Ag/MHC) on the T cell hybridoma D0-11.10, 397 independent T cell hybridomas prepared from BALB/c T cells primed with ovalbumin were screened by ELISA for reactivity with the antibody. Of these T cell hybridomas one, 7D0-286, and a ...

غلاف سوخت‌های هسته‌ای یکی از مهم‌ترین اجزا رآکتور محسوب می‌شود. این غلاف‌ها آلیاژ زیرکونیم ساخته می‌شوند؛ اما خواص ترمومکانیکی چندان مناسبی ندارند؛ لذا در پژوهش سعی شده با تغییر مواد به‌کاررفته NuScale به یک نوترونیکی و مناسب دست پیدا شود. قلب موجب ضریب تکثیر مؤثر طول بازه سوخت‌گذاری می‌گردد. شبیه‌سازی که M5 بهره می‌برد به‌عنوان معیار هم‌­چنین همراه سه نوع دیگر آلیاژهای رایج دو آن FeCrAl است، د...

25 The semen-derived enhancer of viral infection (SEVI) is a positively charged 26 amyloid fibril that is derived from a self-assembling proteolytic cleavage fragment of 27 prostatic acid phosphatase (PAP248-286). SEVI efficiently facilitates HIV-1 infection in 28 vitro, but its normal physiologic function remains unknown. In light of the fact that other 29 amyloidogenic peptides have been show...