نتایج جستجو برای: لوپوس اریتماتوز سیستمیک sle
تعداد نتایج: 11904 فیلتر نتایج به سال:
چکیده ندارد.
Objective(s): Apoptosis is a tightly regulated process and plays a crucial role in autoimmune diseases. Because abnormalities in apoptosis are considered to be involved in the pathogenesis of systemic lupus erythematosus (SLE), in present study we studied the apoptosis in T lymphocytes from Iranian SLE patientsat protein and gene expression levels for some molecules which are involved in apopt...
Background: Cytotoxic lymphocyte antigen-4 (CTLA-4) plays an important role in regulating T cell activation. CTLA-4 gene polymorphisms are related with genetic susceptibility to various autoimmune diseases, including systemic lupus erythematosus (SLE). We analyzed the role of CTLA-4 polymorphisms at positions -318CT in patients who suffer from SLE. Methods: This study was performed on 180 SLE ...
the neuropsychiatric manifestations of systemic lupus erythematosus are frequent. one of the most serious presentations is convulsion. this study was carried out to evaluate the relation between convulsion and anti-dna antibody levels. an analytic, retrospective case-controlled study was carried out, with reference to 1001 recorded cases of systemic sle lupus erythematosus in lupus unit, rheuma...
Introduction: Systemic Lupus Erythematosus (SLE) is an autoimmune disease affect nearly every organ system. Pulmonary involvement, which is a common manifestation of SLE, can remain undiagnosed if asymptomatic. This study aimed to evaluate the efficiency of spirometric findings in early detection of silent pulmonary involvement and examine its correlation with the six minute walk test in SLE pa...
ضرورت این مطالعه از آنجا احساس می گردد که sle یکی از بیماریهای با انسیدانس 1/8 تا 7/6 در یکصد هزار نفر در سال و شیوع جنسی با نسبت زن به مرد حداقل 9 به 1 و حداکثر شیوع در سنی اواخر نوجوانی واوایل جوانی است . و بدن علیه سلولهای خودی آنتی بادی تولید کرده و دارای تنوع علایم بالینی و درگیری سیستم های مختلف می باشد. که تاکنون مطالعه کامل و دقیقی از شیوع - تظاهرات بالینی و آزمایشگاهی آن در دست نبوده ا...
The pathogenesis of systemic lupus erythematosus (SLE) is influenced by both genetic factors and epigenetic modifications; the latter is a result of exposure to various environmental factors. Epigenetic modifications affect gene expression and alter cellular functions without modifying the genomic sequences. CpG-DNA methylation, histone modifications, and miRNAs are the main epigenetic factors ...
Background & Objective: Systemic lupus erythematosus (SLE) is an autoimmune disease with chronic inflammatory immune response. Current therapies mostly rely on glucocorticoids which are accompanied by side-effects and mostly fail to achieve a favorable remission. Th17 subpopulation of T cells is increased in exacerbated SLE as IL-17 cytokine is overexpressed. ...
systemic lupus erythematosus (sle) is a chronic autoimmune disease which results in damage to various organs. some animal studies have revealed that activation of toll-like receptors (tlrs) is important in the pathogenesis of sle. in the present study, the percentage of different immune cell subsets in 35 sle patients and 38 control subjects was analyzed by flow cytometry. we also assessed the ...
Background & Objective: Recent accumulated evidence suggests that prolactin is an important immunomodulator and might have a role in the pathogenesis of systemic lupus erythematosus(SLE). Stimulating immune system, this peptide hormone increases the severity of SLE. The purpose of our study was to assess the frequency of hyperprolactinemia in women with SLE and to evaluate its correlation w...
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