The persistent current (INaP) through voltage-gated sodium channels enhances neuronal excitability by causing prolonged depolarization of membranes. Nav1.3 intrinsically generates a small INaP, although the mechanism underlying its generation remains unclear. In this study, the involvement of the four domains of Nav1.3 in INaP generation was investigated using the tarantula toxin α-hexatoxin-Mr...

The effect of both congenital and acquired factor VII deficiency on the cuticle bleeding time (CBT) was evaluated in dogs. The CBT has been previously documented to be a sensitive indicator of factor VIII:C deficiency in hemophilic dogs. Serial CBT determinations were made on normal dogs treated with high-dose warfarin. At 48 hours post-treatment, the CBT was normal, although the factor VII lev...

BACKGROUND Factor VII is essential for coagulation activation by the extrinsic pathway. Hemorrhages of the central nervous system in patients with congenital factor VII deficiency seem to have a higher incidence compared with other congenital coagulopathies. The purpose of this paper is to report two rare cases of subarachnoid hemorrhage and factor VII deficiency. CASE DESCRIPTION Two cases o...

........................................................................................................................ V SAMMANFATTNING ................................................................................................... VII LIST OF PAPERS ............................................................................................................. IX ABBREVIATIONS ................

Refrigerated display cases are now commonplace in food stores in order to display products in an attractive manner to the customer. An increasing variety of chilled and frozen foods has also added to the demand for more chilled display area but despite this, most modifications to the way supennarket refrigeration systems are designed has come on the high pressure side with little or no regard f...

I review the challenges and problems facing the standard cosmological model, involving an Ω = 1 Universe dominated by non-baryonic dark matter, which arise due to: age estimates of the universe, estimates of the baryon fraction of the universe, and structure formation. Certain of these problems are exacerbated, and certain of these are eased, by the inclusion of some component to the energy den...

................................................................................................................................. III Populärvetenskaplig Sammanfattning .................................................................................. V List of Publications Included in this Thesis ....................................................................... VII List of Publications n...

....................................................................................................................... III RESUME ............................................................................................................................ V TABLE OF CONTENT ...................................................................................................... VII TABLE OF FIGURE...

Solid carbon dioxide exhibits a rich phase diagram at high pressures. Metastable phase III is formed by compressing dry ice above ∼10-12 GPa. Phase VII occurs at similar pressures but higher temperatures, and its stability region is disconnected from III on the phase diagram. Comparison of large-basis-set quasi-harmonic second-order Møller-Plesset perturbation theory calculations and experiment...

Relay-enhanced networks are expected to fulfil the demanding coverage and capacity requirements in a cost-efficient way. Type 1 inband relaying has been standardised as an integral part of the Third Generation Partnership Project (3GPP) LongTerm Evolution Release 10 and beyond (LTE-Advanced). This type of relay nodes (RNs) supports a relaying mode where the RN to donor evolved node B (donor eNB...