prevent cancer by either inhibiting estrogen action or by modulating hepatic metabolism. D-limonene, found in a variety of plants and concentrated in citrus peel oils, also inhibits carcinogen-induced rat mammary tumors by altering both phase I and phase II hepatic enzymes. There is an excellent chapter entitled "Regulation of Carcinogens and Mutagens in Foods in the United States." The current...

oligosaccharide prepared from Pl.-B was eluted as a single peak on both reversed-phase {RP-) HPLC and size-fractionation (SF-) HPLC, and its strueture was estimated to be Manoct-qManal -. 3)(Xylfi1-.2) Manfi1-4GlcNAcfi1-4(Fuc=1-3)GlcNAc by a combination of component analysis, successive exogl)'cosidase digestions, IS-MS anal)'sis, and 500MHz 'H-NMR, Two tryptic gl)'copeptides were isolated from...

The principles involved in the selection of solvents and the use of counter ions, together with the choice of column, for the separation of phospholipids by highperformance liquid chromatography (HPLC) are described.

Penyakit tuberkulosis merupakan suatu gangguan pernapasan yang menular dan penyebabnya dari adanya infeksi bakteri Mycobacterium Tuberkulosis (bakteri aerob). Pengobatan tuberculosis biasa digunakan obat lini pertama yakni isoniazid, rifampisin, etambutol pirazinamid. Tujuan penelitian ini adalah untuk meninjau efektivitas pengembangan metode HPLC atau UPLC dengan detektor UV MS konsentrasi dal...

1 Summary This proposal was for a combined computer simulation and experimental study to develop new tools for designing and optimising chiral HPLC. Of particular interest was to show that it is now feasible to perform realistic molecular simulations of HPLC, and that such simulations can aid in the design and optimisation of HPLC columns. In particular, it was proposed to carry out a combined ...

BACKGROUND HPLC is currently the preferred method for accurate measurement of mycophenolic acid (MPA). This study was designed to validate the Emit compared with HPLC in relation to clinical outcome measurements. METHODS Pediatric renal-transplant recipients (n = 50) on an immunosuppressive triple regimen consisting of cyclosporin A, prednisone, and mycophenolate mofetil (600 mg/m(2) twice pe...

BACKGROUND The Afinion HbA1c (Axis-Shield) is a newer point-of-care device for measurement of hemoglobin A1c (A1C) using a boronate affinity method unlike the more commonly used DCA immunoassay method (Siemens Medical Solutions Diagnostics). The Afinion's accuracy and precision, when compared with high-performance liquid chromatography (HPLC) and DCA methods, have not been established in pediat...

Black cohosh has been widely used as an herbal medicine for the treatment of symptoms related to menopause in America and Europe during the past several decades, but the bioactive constituents are still unknown. Formononetin is an isoflavone with known estrogen-like activity. This compound was first reported to be isolated from black cohosh in 1985, but subsequent research in 2002 using HPLC-PD...

BACKGROUND fms-related tyrosine kinase 3 (Flt3) is the most commonly mutated gene in human acute myeloid leukemia (AML) and has been implicated in its pathogenesis. Because screening of Flt3 in AML patients by PCR followed by gel electrophoresis is time-consuming and fails to detect some very small internal tandem duplications (ITDs), we developed a method for screening of FLT3 receptor mutatio...

BACKGROUND We developed a simple and inexpensive thin-layer chromatography (TLC) assay for semiquantitative detection of saliva concentrations of nevirapine in resource-limited settings. The method was validated in an African target population. METHODS Paired plasma and saliva nevirapine concentrations were assayed by high-performance liquid chromatography (HPLC); saliva concentrations of nev...