Familial hemophagocytic lymphohistiocytosis (FHL) is an inherited, fatal disorder of infancy. We report here a 17-day-old female infant who presented with high fever, hepatosplenomegaly, hypertriglyceridemia, hypofibrinogenemia, thrombocytopenia, and liver failure. Leukocytosis was detected with circulating "atypical" lymphoid cells. Flow cytometric studies revealed expanded subpopulations of C...

the aim of this study was to investigate the effects of an acute bout of exhaustive resistance exercise on the expression of myogenesis modulators (myostatin (mstn) and myod) in male trained and untrained wistar rats’ fast and slow muscles. thirty rats were assigned to three groups: control (n=6), untrained (n=12) and trained (n=12). resistance exercise (weight lifting up a vertical ladder) was...

The sessile nature of plants has promoted the evolution a wide range mechanisms that enable to adapt changing environment. In particular, light environment is highly dynamic and, therefore, have evolved several families photoreceptors detect almost all facets light, such as quality, quantity, direction, and duration. Phytochromes are red (R) far-red (FR) in play fundamental roles modulating ada...

Mutations of familial hemophagocytic lymphohistiocytosis (FHL) related genes and abnormalities of cytotoxicity function tests in patients with macrophage activation syndrome (MAS) occurring in systemic juvenile idiopathic arthritis (sJIA) Claudia Bracaglia, Elena Sieni, Martina Da Ros, Carmela De Fusco, Concetta Micalizzi, Valentina Cetica, Benedetta Ciambotti, Maria Luisa Coniglio, Antonella I...

PURPOSE This study was designed to determine the appropriate Leucine intake volume to obtain the effects of restoring damaged muscle through the synthesis of muscle proteins to increase skeletal muscle and improve exercise performance, and to achieve enhanced muscle hypertrophy. METHODS To clarify the effects of leucine on skeletal muscle hypertrophy of SD rats, following eight weeks of resis...

Hemophagocytic lymphohistiocytosis (HLH) can be divided into primary (genetic or familial) and secondary (acquired or reactive) forms. Abnormal immunophenotyping and downregulation of CD5 or CD7 in T cells have been well characterized in EpsteinBarr virus (EBV)-associated HLH [1, 2]. A few studies have also reported abnormal immunophenotyping of T cells in patients with familial HLH (FHL) [1, 3...

Hemophagocytic lymphohistiocytosis (HLH) is a disease with major diagnostic and therapeutic difficulties. HLH comprises two different conditions that may be difficult to distinguish from one another: a primary [1] and a secondary form [2]. The primary autosomal recessive form, familial hemophagocytic lymphohistiocytosis (FHL), has an estimated incidence of around 1:50,000 live-born children [3]...