Intracellular membranes are critical for replication of positive-strand RNA viruses. To dissect the roles of various lipids, we have developed an artificial phosphatidylethanolamine (PE) vesicle-based Tomato bushy stunt virus (TBSV) replication assay. We demonstrate that the in vitro assembled viral replicase complexes (VRCs) in artificial PE vesicles can support a complete cycle of replication...

Despite a high mortality rate, no specific treatment for severe fever with thrombocytopenia syndrome (SFTS) has been established. This study compared the clinical outcomes of SFTS patients treated with plasma exchange (PE group) with those who were not treated (non-PE group) at nine Korean hospitals between May 2013 and August 2015. A total of 53 SFTS patients were included: 24 (45.3%) PE cases...

BACKGROUND A pulmonary embolism (PE) is thought to be associated with atrial fibrillation (AF). Nevertheless, this association is based on weak data. OBJECTIVES To assess whether the presence of AF influences the clinical probability of PE in a cohort of patients with suspected PE and to confirm the association between PE and AF. PATIENTS/METHODS We retrospectively analyzed the data from tw...

Acute pulmonary embolism (PE) is a life-threatening disease, and several vasoconstrictors, including endothelin-1 (ET-1), play a key role in vasoconstriction and hypoxemia during the development of PE. Rho kinase is activated by various vasoconstrictors resulting in vascular contraction and remodeling. Recent evidence has revealed an important role of Rho kinase in the pathogenesis of systemic ...

This randomized controlled trial investigated whether adding the psychodynamically based body-oriented psychotherapy "Functional Relaxation" (FR) to psychoeducation (PE) is more effective than PE alone to reduce stress and stress-associated complaints. Eighty-one participants with elevated stress-levels, ≥50 points on the global scale of the Perceived Stress Questionnaire (PSQ), received either...

evaluation of functional disability using proper instruments, like health assessment questionnaire (haq) in patients with rheumatoid arthritis (ra), is necessary not only for quality of life assessment, but also as a useful marker for disease activity. haq has been translated into many languages. to validate the persian version of stanford haq. persian version of the haq (pe-haq) with culturall...

background: preeclampsia (pe) is one of the most complex and life-threatening pregnancy disorders and is considered as a major cause of mortality among mothers and fetuses worldwide. although the exact etiology of pe is not well known several lines of evidence support an immunological etiology for pe. objective: to investigate the differences in the expression of tlrs 2, 4, 5, and 6 and a group...

BACKGROUND We investigated viscoelastic properties of the arterial wall in women with previous preeclampsia (PE) compared to those with normal pregnancy (NP). METHODS In a cross-sectional study 45 women with previous PE and 55 with NP were included, matched for age (PE 38±6 vs. NP 38±5 years, NS) and body mass index: (PE 25±4 vs. NP 26±4 kg/m(2), NS) studied, respectively, 76±34 and 86±48 mon...

(1) Paraíba State Health Secretary, João Pessoa, PB, Brazil. (2) FUNESO, Olinda, PE, Brazil. (3) Oswaldo Cruz Foundation – Aggeu Magalhães Research Center, Recife, PE, Brazil. (4) Federal University of Pernambuco – UFPE, Recife, PE, Brazil. (5) Servidores Hospital of the Pernambuco State/Human Resources Institute, Recife, PE, Brazil. (6) Federal University of Pernambuco – UFPE, Recife, PE, Braz...

Poplitealvenous aneurysms (PVA) are associated with deep venous thrombosis and recurrentpulmonary thromboembolism (PE). We report three cases of PVA. In all three patients the first sign of PVA was acute PE; in one case, the PE was recurrent. Computed tomography and duplex ultrasonography revealed not only PE but also popliteal venous dilatation with thrombus. Surgical reconstruction was perfor...