Conclusion. Vaccinated individuals were more likely than unvaccinated individuals to benefit from antiviral treatment. This finding warrants confirmation in other populations. Disclosures. A. S. Monto, sanofi pasteur: Grant Investigator, Research grant. Novartis: Consultant, Consulting fee. Protein Sciences: Consultant, Consulting fee. E. T. Martin, Pfizer: Scientific Advisor, Research grant. M...

conception of the invention. To explain this important distinction, the Enlarged Board applied its approach to a hypothetical invention concerning an improved copying machine. 124 The Enlarged Board explained that article 53(a) would not necessarily preclude patentability merely because one embodiment contained unclaimed features that would enable counterfeiting money.1 In particular, it stated...

From its introduction, the antibiotic tobramycin has been an important tool in the management of persons with cystic fibrosis (CF) and chronic Pseudomonas aeruginosa lung infections. Initially an intravenous rescue treatment for pulmonary exacerbations, tobramycin delivered by inhalation has become a mainstay of chronic suppressive CF infection management. Platforms for tobramycin aerosol deliv...

The autoinflammatory syndromes are a group of multisystem disorders characterized by recurrent episodes of fever and systemic inflammation affecting the eyes, joints, skin, and serosal surfaces. These syndromes differ from autoimmune diseases by several features, including the periodicity whereas autoimmune diseases are progressive, and the lack of signs of involvement of adaptive immunity such...

In the article cited above, the duality of interest for author Emily B. Schroeder reads “E.B.S. received industry-sponsored research support from Novartis, Merck Sharpe & Dohme, Boehringer Ingelheim, AstraZeneca, andBristol-Myers Squibb.” The author has requested that this be corrected to read “E.B.S. was supported by National Institute of Diabetes and Digestive and Kidney Diseases grant K23DK0...

Present address: Novartis Institute of Biomedical Research, Basel 4056, Switzerland. Present address: Inspiralis Ltd., Norwich Bioincubator, Norwich Research Park Colney Lane, Norwich, NR4 7UH, UK To whom correspondence may be addressed: Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK. Tel +44-1603-450771; Fax +44-1603-450018, Email tony.maxwel...

High blood pressure is a major risk factor for cardiovascular disease worldwide.1 Drug treatments include those that target the renin-angiotensin system, a key hormone cascade in the regulation of blood pressure. One of these is ▼aliskiren (Rasilez – Novartis), which belongs to a new class of drugs, direct renin inhibitors.2 Here we assess its place in managing adults with hypertension. BNF 2.5...

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL; The University of Texas MD Anderson Cancer Center, Houston, TX; Stanford Cancer Center and Stanford University School of Medicine, Palo Alto, CA; Duke University Medical Center, Durham, NC; Novartis Pharmaceuticals Corporation, East Hanover, NJ; and Winship Cancer Inst...

هدف انتخاب تأمین‌کنندگان و تخصیص سفارش بر اساس ابعاد پایداری ریسک پایداری، در شرایط عدم‌­قطعیت برخی پارامترها است؛ همچنین با محدودیت استراتژی کاهش برای مدیریت همراه است. معیارهای ریسک، امتیاز توسط روش‌های تاپسیس فازی تجزیه‌وتحلیل آثار شکست محاسبه شده است سپس برنامه تصادفی چندمرحله‌ای ایجاد معیار ارزش معرض شرطی، پیرامون تأمین منابع یک فضای چند­دوره‌ای برنامه‌‎ریزی دستیابی به برنامه‌ریزی انعطاف‌پ...

KJM has received honoraria from Janssen, LEO Pharma, Lilly and Novartis. ADB consults lectures for Abbvie, Amgen, Boehringer Ingelheim, Celgene, Lilly, Novartis Pfizer. JNWN advisory boards at sponsored symposia together with grants research in the past 5 years AbbVie, Novartis, CEK and/or funding Galderma, GSK-Stiefel, Johnson & Johnson, Pfizer UCB Pharma. KM CEMG Actelion, Almirall, MSD, Pfiz...