The flagellated protozoan Giardia duodenalis (syn. lamblia or intestinalis) has been chosen as a model parasite to further investigate the multifunctional 14-3-3s, a family of highly conserved eukaryotic proteins involved in many cellular processes, such as cell cycle, differentiation, apoptosis, and signal transduction pathways. We confirmed the presence of a single 14-3-3 homolog gene (g14-3-...

In this study, the growth of sixty-one bacterial strains in crude oil were determined spectrophotometrically at 620 nm. Pseudomonas aeruginosa G1, Pseudomonas fluorescens G6, Pseudomonas stutzeri G11 and Pseudomonas putida G15 were chosen for the study based on the efficiency of crude oil utilisation. At 1% (v/v) crude oil concentration, P. stutzeri G11 strain degraded a maximum of 69%. The per...

The short chain fatty acid receptor FFA2 is able to stimulate signaling via both Gi- and Gq/G11-promoted pathways. These pathways are believed to control distinct physiological end points but FFA2 receptor ligands appropriate to test this hypothesis have been lacking. Herein, we characterize AZ1729, a novel FFA2 regulator that acts as a direct allosteric agonist and as a positive allosteric mod...

Echinococcus multilocularis causes alveolar echinococcosis, one of the most lethal helminthic (accidental) infections in humans, as the life cycle predominantly includes wildlife rodents as intermediate hosts. The physical barrier between the proliferating parasitic metacestode and the host tissue is the acellular laminated layer (LL), which is characterized by its rich high-molecular-weight po...

A novel human rotavirus strain, CUK-1, containing a G11 type combined with a P[4] type was isolated from a 1-year-old female patient with fever and severe diarrhea at Our Lady of Mercy Hospital in Incheon, South Korea. This CUK-1 strain showed the highest degree of nucleic acid similarity (98.7% and 93%) to G11 Dhaka6 and P[4] RV 5, respectively. This novel combined type of CUK-1 rotavirus stra...

ارتقای بازدارندگی دفاعی مستلزم تولید گسترده و متنوع محصولات تجهیزات نظامی است که نیازمند به‌کارگیری ظرفیت‌ها قابلیت‌های وسیع صنعتی است. ازآنجاکه تصدی تملک همه این قابلیت‌ها منطقی اقتصادی نیست، بخشی از فعالیت‌های تولیدی در صنایع دفاعی، برون‌سپاری می­‌شود به ایجاد شبکه بزرگی تأمین‌کنندگان منجر شده گستردگی شبکه، تعاملات همکارانه بهبود عملکرد زنجیره تأمین را یک چالش جدی برای مدیران تبدیل کرده سازما...

A total of 12 diverse tomato genotypes as parents and their 32 hybrids, obtained through Line × tester mating fashion, were evaluated to observe the consequence different genetic parameters on yield contributing traits. The experiment was conducted during two consecutive years 2016-2017 2017-2018 winter seasons in a Randomized Complete Block Design (RCBD) with three replications. analysis varia...

Anaphylactic shock is a severe allergic reaction involving multiple organs including the bronchial and cardiovascular system. Most anaphylactic mediators, like platelet-activating factor (PAF), histamine, and others, act through G protein-coupled receptors, which are linked to the heterotrimeric G proteins G(q)/G(11), G(12)/G(13), and G(i). The role of downstream signaling pathways activated by...