NMDA receptors mediate excitatory synaptic transmission and regulate synaptic plasticity in the central nervous system, but their dysregulation is also implicated in numerous brain disorders. Here, we describe GluN2A-selective negative allosteric modulators (NAMs) that inhibit NMDA receptors by stabilizing the apo state of the GluN1 ligand-binding domain (LBD), which is incapable of triggering ...

MOTIVATION Mixed linear models provide important techniques for performing genome-wide association studies. However, current models have pitfalls associated with their strong assumptions. Here, we propose a new implementation designed to overcome some of these pitfalls using an empirical Bayes algorithm. RESULTS Here we introduce NAM, an R package that allows user to take into account prior i...

Axonal damage is a major morphological alteration in the CNS of patients with multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). However, the underlying mechanism for the axonal damage associated with MS/EAE and its contribution to the clinical symptoms remain unclear. The expression of a fusion protein, named "Wallerian degeneration slow" (Wld(S)), c...

From 1956-70 among 6,668 female cancers, 3,023 cases (45% of female cancers) were cervical cancer reported by medical institutions in Ho Chi Minh City (HCM), south Viet Nam, (Hoanh et al., 1976). Thereafter, from 1976-81, a very high frequency of cervical cancer was also reported: 53% of the female cancer patients (3,602 of 6,757 cases) treated in the Central Oncology of Ho Chi Minh City, (Truo...

This paper presents a study on the interpretation and bracketing of noun compounds (“NCs”), based on lexical semantics. Our primary goal is to develop a method to automatically interpret NCs through the use of semantic relations. Our NC interpretation method is based on lexical similarity with tagged NCs, based on lexical similarity measures derived fromWordNet. We apply the interpretation meth...

The competition graph of a digraph, introduced by Cohen in 1968, has been extensively studied. More recently, in 2000, Cho, Kim and Nam defined the m-step competition graph. Here, we offer another generalization of the competition graph. We define the (1,2)-step competition graph of a digraph D, denoted C1,2(D) , as the graph of V(D) where {x,y} is an element of E(C1,2(D)) if and only if there ...

[1] We find that the North Annular Mode (NAM) of the wintertime geopotential height anomalies between 10 and 1000 hPa is influenced by solar changes and that the effect is statistically significant. This evidence suggests that a mechanism of solar influence on climate operates through the excitation of this mode. The influence depends on the phase of the quasi-biennial oscillation (QBO). In ear...

Password-Authenticated Key Exchange (PAKE) protocols allow parties to share secret keys in an authentic manner based on an easily memorizable password. Recently, Nam et al. showed that a provably secure three-party passwordbased authenticated key exchange protocol using Weil pairing by Wen et al. is vulnerable to a man-in-the-middle attack. In doing so, Nam et al. showed the flaws in the proof ...

The adaptor protein STAC3 is essential for skeletal muscle excitation-contraction (EC) coupling and a mutation in the STAC3 gene has been linked to a severe muscle disease, Native American myopathy (NAM). However the function of STAC3, its interaction partner, and the mode of interaction within the EC-coupling complex remained elusive. Here we demonstrate that STAC3 forms a stable interaction w...

Nicotinamide phosphoribosyltransferase (NAMPT) is highly evolved to capture nicotinamide (NAM) and replenish the nicotinamide adenine dinucleotide (NAD(+)) pool during ADP-ribosylation and transferase reactions. ATP-phosphorylation of an active-site histidine causes catalytic activation, increasing NAM affinity by 160,000. Crystal structures of NAMPT with catalytic site ligands identify the pho...