Precise preoperative identification of the collateral venous anastomoses is critical for proper surgical management of patients with meningioma involving sinus. This study was to assess the feasibility of susceptibility weighted imaging (SWI) to delineate the collateral venous anastomoses before surgery. Twenty-five patients with meningiomas that were involved in sinuses underwent surgery and t...

BACKGROUND Susceptibility-weighted (SW) MRI provides insight into the pathophysiology of acute stroke. We report on the use of SW imaging (SWI) sequences in clinical practice and highlight the future applications. SUMMARY OF REVIEW SWI exploits the magnetic susceptibility effects generated by local inhomogeneities of the magnetic field. The paramagnetic properties of deoxyhemoglobin support s...

Tissue-specific transcriptional activators initiate differentiation towards specialized cell types by inducing chromatin modifications permissive for transcription at target loci, through the recruitment of SWItch/Sucrose NonFermentable (SWI/SNF) chromatin-remodelling complex. However, the molecular mechanism that regulates SWI/SNF nuclear distribution in response to differentiation signals is ...

PURPOSE To demonstrate a novel contrast mechanism for imaging the vessel wall and vessel wall calcification using susceptibility-weighted imaging (SWI). MATERIALS AND METHODS Eighteen subjects were imaged with multidetector computed tomography (MDCT) and high-resolution SWI at 3T. The SWI imaging parameters were optimized to allow for the best visualization of the femoral artery lumen and the...

Subunits of the SWI/SNF chromatin remodeling complex are frequently mutated in human cancers leading to epigenetic dependencies that are therapeutically targetable. The dependency on the polycomb repressive complex (PRC2) and EZH2 represents one such vulnerability in tumors with mutations in the SWI/SNF complex subunit, SNF5; however, whether this vulnerability extends to other SWI/SNF subunit ...

BACKGROUND Specific morphologic features of hepatocellular carcinoma (HCC) on imaging have identifiable pathologic correlates as well as implications for altering surgical management and defining prognosis. In this study, we compared susceptibility-weighted imaging (SWI) to conventional techniques and correlated our findings with histopathology to determine the role of SWI in assessing morpholo...

Purpose As SWI is taking advantage of susceptibility of tissues and vessels to provide a new special image contrast which is different from conventional T1, T2 and Proton Density weighted contrast, it has been proven to be of great value to clinical diagnosis for human brain diseases. In this study we extended SWI application from human brain to abdomen (cirrhosis in this study) at 3T to see if...

Introduction: The occurrence of subarachnoid hemorrhage (SAH) in traumatic brain injury (TBI) is 12% ~ 53% and related to poor outcome (1, 2). Early diagnosis of SAH and active intervention in removing hemorrhage from subarachnoid space is of great significance in the management of acuteTBI. Susceptibility weighted imaging (SWI) has been successfully applied in TBI and proved to be 6 times more...

Monitoring of water cover and shorelines at a global scale is essential for better understanding climate change consequences and modern human disturbances. The level and turbidity of the surface water, and the background objects in which they interact with, vary significantly at a global scale. The existing water indices applicable to detection and extraction of water cover at local and regiona...

RNA-mediated transcriptional silencing prevents deleterious effects of transposon activity and controls the expression of protein-coding genes. It involves long noncoding RNAs (lncRNAs). In Arabidopsis thaliana, some of those lncRNAs are produced by a specialized RNA Polymerase V (Pol V). The mechanism by which lncRNAs affect chromatin structure and mRNA production remains mostly unknown. Here ...