In most diffusion tensor imaging (DTI) studies, images are acquired with either a partial-Fourier or a parallel partial-Fourier echo-planar imaging (EPI) sequence, in order to shorten the echo time and increase the signal-to-noise ratio (SNR). However, eddy currents induced by the diffusion-sensitizing gradients can often lead to a shift of the echo in k-space, resulting in three distinct types...

We review the current knowledge concerning clinical applications of the advanced technique of magnetic resonance imaging (MRI): diffusion tensor imaging (DTI) of the spinal cord. Due to technical difficulties, DTI has rarely been used in spinal cord diseases. However, in our opinion it is potentially a very useful method in diagnosis of the different pathological processes of the spinal cord an...

We have used MR DTI to identify relevant brain structures involved in visuospatial processing, in an attempt to link perceptual and attentional impairments to WM changes in Alzheimer’s disease (AD) patients. Correlation of DTI measured parameters with results of several neuropsychological tests will be reported here. Several issues related to quantitation of DTI parameters in ROI analysis are a...

Introduction: In recent years, voxel based analysis (VBA) studies have demonstrated the potential of diffusion tensor imaging (DTI) to detect white matter (WM) damage in patients with various neurological or psychiatric disorders. In VBA, all DTI data sets are transformed to an atlas or template, whereafter the diffusion measures of control subjects and patients are evaluated in each voxel. In ...

BACKGROUND AND PURPOSE DTI in the brain has been well established, but its application in the spinal cord, especially in pediatrics, poses several challenges. The small cord size has inherent low SNR of the diffusion signal intensity, respiratory and cardiac movements induce artifacts, and EPI sequences used for obtaining diffusion indices cause eddy-current distortions. The purpose of this stu...

Examinations of probabilistic tractography have identified major tracts across the brain, but little has been done to compare them to wellestablished tracer studies. Therefore, diffusion tensor imaging (DTI) probabilistic tractography of white matter (WM) was performed on a DTI template generated from 271 rhesus macaques. Injection sites from tracer experiments in literature were chosen as seed...

We discuss the use of MRI in detecting and staging white matter reorganization after brain injury with and without neurorestorative treatment. Based on variations of diffusion tensor MRI (DTI) methodology, we demonstrate that MRI can detect white matter remodeling after brain injury. In addition, we demonstrate that Q-space DTI can detect early stage axonal remodeling, which involves randomly o...

This study aimed to examine, using diffusion tensor imaging (DTI), differences in electrode placement in four patients undergoing deep brain stimulation for chronic neuropathic pain of varying aetiology. A pre-operative DTI was obtained for each patient, who was then implanted with deep brain stimulation electrodes in the periventricular/periaqueductal grey area with good pain relief. Using see...

Introduction: Diffusion tensor imaging (DTI) is a non-invasive MR imaging technique that can be used to probe in-vivo the microstructural properties of brain tissue [1]. Accurate inter-subject spatial normalization of DTI data is crucial for voxel-based comparisons of neuronal structural integrity [2] and brain connectivity [3] across populations, as well as for the development of a white matte...