Camptothecin or CPT and its analogs appear to employ anticancer action by poisoning topoisomerase I (topo I) enzyme. As a result topo I activity inhibited and have established important role against a wide range of tumors. CPT was extracted from bark of Chinese plant Camptotheca acuminate but now a large number of synthetic and semi-synthetics are identified. After activity, researchers organiz...

In Camptotheca acuminata, we studied the cellular sites of accumulation of the alkaloid camptothecin (CPT), in both plants grown in the field and those grown in a greenhouse, subjecting the latter to stress (i.e., draught, nutritional deficit, and pruning). Fresh sections of the leaf, stem, and root were analysed for the presence of CPT by examining the autofluorescence that the CPT molecule em...

The feasibility of placing bounds on CPT violation from experiments with neutral-B mesons is examined. We consider situations with uncorrelated mesons and ones with either unboosted or boosted correlated mesons. Analytical expressions valid for small Tand CPT-violating parameters are presented for time-dependent and time-integrated decay rates, and various relevant asymmetries are derived. We u...

In this talk, we investigate extrinsic CPT violation in neutrino oscillations in matter with three flavors. Note that extrinsic CPT violation is different from intrinsic CPT violation. Extrinsic CPT violation is one way of quantifying matter effects, whereas intrinsic CPT violation would mean that the CPT invariance theorem is not valid. We present analytical formulas for the extrinsic CPT prob...

Patients treated with high doses of CPT-11 rapidly develop a cholinergic syndrome that can be alleviated by atropine. Although CPT-11 was not a substrate for acetylcholinesterase (AcChE), in vitro assays confirmed that CPT-11 inhibited both human and electric eel AcChE with apparent K(i)s of 415 and 194 nM, respectively. In contrast, human or equine butyryl-cholinesterase (BuChE) converted CPT-...

Experimental signals for indirect CPT violation in the neutral-meson systems are studied in the context of a general CPTand Lorentz-violating standard-model extension. In this explicit theory, some CPT observables depend on the meson momentum and exhibit diurnal variations. The consequences for CPT tests vary significantly with the specific experimental scenario. The wide range of possible effe...

With CPT-invariant initial conditions that commute with CPT-invariant final conditions, the respective probabilities (when defined) of a set of histories and its CPT reverse are equal, giving a CPT-symmetric universe. This leads me to question whether the asymmetry of the Gell-Mann–Hartle decoherence functional for ordinary quantum mechanics should be interpreted as an asymmetry of time . PACS ...

A theoretical study of possible signals for CPT and Lorentz violation arising in hydrogen and antihydrogen spectroscopy is described. The analysis uses a CPTand Lorentz-violating extension of quantum electrodynamics, obtained from a general Lorentz-violating extension of the minimal standard model with both CPT-even and CPT-odd terms. Certain 1S-2S transitions and hyperfine Zeeman lines exhibit...