A40 Persistent circulation of highly divergent HIV-1M lineages in the Congo Basin Region M. Tongo, J.R. Dorfman, Tulio de Oliveira, D.P. Martin, Africa Centre for Population Health, University of KwaZulu-Natal, South Africa, Division of Computational Biology and Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa, Institute of Medical Research and Stud...

A standardization body (CAPE-OPEN Laboratories Network – CO-LaN) has been established to maintain and disseminate the software standards in the Computer Aided Process Engineering (CAPE) domain that have been developed in the international projects CAPE-OPEN and Global CAPE-OPEN. The CO-LaN ensures that software tools used by the process industries reach a level of interoperability that will hel...

UNLABELLED ETHNOPHARMACOLOGICAL CONTEXT: Cape herbal medicine as a distinct and unique healing system is conceptualized for the first time, together with a first compilation of the authentic materia medica of the system. MATERIALS AND METHODS The early literature on Khoikhoi (Hottentot), San (Bushman) and Cape Dutch medicinal plants and medical practices is reviewed, with a focus on the Cape ...

We have previously examined the antiproliferative activity of caffeic acid phenethyl ester (CAPE) and its 20 analogues against six tumor cell lines, and found that CAPE analogues possess selective antiproliferative activity toward the murine colon 26-L5 carcinoma cell line. To extend our study, the effects of CAPE analogues on the metastatic development of murine colon 26-L5 carcinoma cells in ...

OBJECTIVE The aim of this study was to investigate the effects of antioxidant molecules melatonin and caffeic acid phenethyl ester (CAPE) on fracture healing under ischemic conditions. METHODS A right tibia fracture was created and fixed with an intramedullary pin in forty four male Wistar-albino rats. The rats were then randomly allocated to fracture, fracture-ischemia, fracture- ischemia-me...

Author details Centre for Health Communication and Participation, Australian Institute for Primary Care & Ageing, La Trobe University, Bundoora, VIC 3086, Australia. Norwegian Knowledge Centre for the Health Services, PO Box 7004, St. Olavs plass, N-0130, Oslo, Norway. Health Systems Research Unit, Medical Research Council of South Africa, Cape Town, South Africa. International Union for Health...

BACKGROUND AND AIM The aim of this study was to determine the actions of caffeic acid phenethyl ester (CAPE) on the changes of endothelin-1 (ET-1) level, tumor necrosis factor- (TNF-) alpha, and oxidative stress parameters such as superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in experimental sepsis model in rats. MATERIALS AND METHODS Twenty-four rats were randomly di...

Natural polyphenols have been observed to possess antiproliferative properties. The effects, including apoptotic potential of bioactive phenolic compounds, caffeic acid (CA) and its derivative caffeic acid phenethyl ester (CAPE), on cell proliferation and apoptosis in human head and neck squamous carcinoma cells (HNSCC) line (Detroit 562) were investigated and compared. Cancer cells apoptosis r...

BACKGROUND Vascular endothelial growth factor (VEGF) is a key regulator of pathogenic angiogenesis in diseases such as cancer and diabetic retinopathy. Bee products [royal jelly (RJ), bee pollen, and Chinese red propolis] from the honeybee, Apis mellifera, have been used as traditional health foods for centuries. The aim of this study was to investigate the anti-angiogenic effects of bee produc...

1. Division of Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa 2. South African Rugby Union (SARU), SARU House, 163 Uys Krige Road, Plattekloof, Cape Town, South Africa 3. Department of Public & Occupational Health and the EMGO Institute for Health and Care Research, VU University Medical Center, Ams...