Acute kidney disease (AKI) leads to increased risk of progression to chronic kidney disease (CKD). Antithrombin III (ATIII) is a potent anticoagulant with anti-inflammatory properties, and we previously reported that insufficiencies of ATIII exacerbated renal ischaemia-reperfusion injury (IRI) in rats. In this study, we examined the characteristic of AKI-CKD transition in rats with two distinct...

Ischemia-reperfusion injury (IRI) is one of the major causes of acute kidney injury (AKI) and evidence supporting the involvement of both innate and adaptive immunity in renal IRI has accumulated in recent years. In addition to leukocytes, kidney endothelial cells promote inflammation after IRI by increasing adhesion molecule expression and vascular permeability. Kidney tubular epithelial cells...

INTRODUCTION Hepatic ischemia/reperfusion injury (IRI) occurs during liver transplantation, tumor resection, hemorrhagic shock and veno-occlusive disease, and is a major cause of acute liver failure which associated with high morbidity and mortality. IRI in liver is also responsible for early organ failure and increased incidence of both acute and chronic rejection after liver transplantation. ...

In this paper, we study virtual full-duplex (FD) buffer-aided relaying to recover the multiplexing loss of halfduplex (HD) relaying in a network with multiple buffer-aided relays, each of which has multiple antennas, through opportunistic relay selection and beamforming. The main idea of virtual FD buffer-aided relaying is that a source and a relay simultaneously transmit their own information ...

Prostate apoptosis response-4 (Par-4) is a leucine zipper protein linked to apoptotic cell death in prostate cancer and neuronal tissues. The leucine zipper domain of Par-4 (Leu.zip) mediates protein-protein interactions that are essential for sensitization of cells to apoptosis, and overexpression of Leu.zip blocks Par-4 activity in a dominant negative fashion. Ischemia-reperfusion-induced ren...

Background: The widely adopted Jablonski scoring system for reporting histological damage in kidney ischaemia reperfusion injury (IRI) provides a limited score documenting the degree of necrosis within tubular cells. IRI is a complex process that involves damage to various cellular components of the renal cortex and therefore there is a need to develop a more detailed scoring system. The aims o...

Ischemia and reperfusion injury (IRI) is a crucial contributor to the development of renal fibrosis. Ozone has been proposed as a novel medical therapy for various conditions, including organ IRI. The aim of this study was to investigate whether ozone oxidative preconditioning (OzoneOP) has a beneficial effect in preventing the development of renal fibrosis following IRI. Sprague Dawley rats we...

in this paper, we study the existence of coupled coincidence andcoupled common fixed points for single-valued and fuzzy mappingsunder a contractive condition in metric space. presented theoremsextend and improve the main results of abbas and$acute{c}$iri$acute{c}$ {itshape et al.} [m. abbas, l.$acute{c}$iri$acute{c}$, {itshape et al.}, coupled coincidenceand common fixed point theorems for hybr...

Mesenchymal stem cells (MSCs) are a potential therapeutic tool for preventing the progression of acute kidney injury (AKI) to chronic disease (CKD). Herein, we investigated localization and maintenance engrafted human bone marrow-derived MSCs in rats subjected renal ischemia-reperfusion (IRI) compared effectiveness two intravascular injection routes via artery or inferior vena cava. Renal was m...