Mammalian bile acids (BAs) are oxidized metabolites of cholesterol whose amphiphilic properties serve in lipid and cholesterol uptake. BAs also act as hormone-like substances that regulate metabolism. The Caenorhabditis elegans clk-1 mutants sustain elevated mitochondrial oxidative stress and display a slow defecation phenotype that is sensitive to the level of dietary cholesterol. We found tha...

Outline of this Report The Bavarian Archive for Speech Signals (BAS) is a joint initiative of the Bavarian State and the Ludwig Maximilians Universität München. It is located at the host organisation Institut für Phonetik und Sprachliche Kommunikation and collects, evaluates, produces and disseminates speech based resources to the scientific community. Our focus is the German language covering ...

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Bile acids (BAs) exert pleiotropic metabolic effects, and physicochemical properties of different BAs affect their function. In rodents, insulin regulates BA composition, in part by regulating the BA 12α-hydroxylase CYP8B1. However, it is unclear whether a similar effect occurs in humans. To address this question, we examined the relationship between clamp-measured insulin sensitivity and plasm...

Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency of premature infants. Previously, we showed that luminal bile acids (BAs) are increased and correlated with disease development and that the apical sodium-dependent BA transporter (ASBT), which transports BAs from the ileal lumen into enterocytes, is upregulated in rats with NEC. We hypothesized that intraenterocyte, ...

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β-asarone (BAS) is an active component of Acori graminei rhizoma, a traditional medicine used clinically in treating dementia and chronic stress in Korea. However, the cognitive effects of BAS and its mechanism of action have remained elusive. The purpose of this study was to examine whether BAS improved spatial cognitive impairment induced in rats following chronic corticosterone (CORT) admini...

Since antiquity, artisans have created attened forms, often called \bas-reliefs," which give an exaggerated perception of depth when viewed from a particular vantage point. This paper presents an explanation of this phenomena, showing that the ambiguity in determining the relief of an object is not con ned to bas-relief sculpture but is implicit in the determination of the structure of any obje...