Medullary thyroid cancer (MTC) occurs in less than 1% of thyroid nodules and accounts for 5-10% of thyroid malignancies. It is a well-differentiated neuroendocrine carcinoma arising from parafollicular calcitonin-producing cells (C-cells) of the thyroid gland and is associated with elevated serum calcitonin levels. Among well-differentiated thyroid carcinomas, MTC is the most aggressive, with s...

Medullary thyroid carcinoma (MTC), a neuroendocrine tumor originating from thyroid parafollicular cells, has been demonstrated to be associated with mutations in RET, HRAS, KRAS and NRAS. However, the role of other genes involved in the oncogenesis of neural crest tumors remains to be fully investigated in MTC. The current study aimed to investigate the presence of somatic mutations in BRAF, CD...

The mean temperature of the catch (MTC), which is the average inferred temperature preference of the exploited species weighted by their annual catch, is an index that has been used for evaluating the effect of sea warming on marine ecosystems. In the present work, we examined the effect of sea surface temperature (SST) on the catch composition of the Greek Seas using the MTC applied on the off...

BACKGROUND Medullary thyroid carcinoma (MTC) may occur either as sporadic or as hereditary. Even though the sporadic form corresponds to the majority of cases, the pathogenesis is still unclear. Several polymorphisms of the ret proto-oncogene, including those located in exon 11, 13, 14 and 15 have been described in the general population and some of them seem to be over-represented in sporadic ...

introduction: medullary thyroid carcinoma (mtc) is a rare thyroid cancer secreting calcitonin (ct) which is the most sensitive and specific tumor marker for mtc. this type of thyroid cancer is able to metastasize to different body areas including regional lymph nodes, lungs, liver and bone. the aim of this study was to assess the sensitivity and specificity of [99mtc-dmsa (v)] whole body scan (...

IT is our honor to serve as guest editors of this special section of the IEEE Transactions on Parallel and Distributed Systems (TPDS) on many-task computing (MTC). This section focuses on the methods required to manage and execute large multiple program multiple data (MPMD) computations on large clusters, grids, clouds, and supercomputers. We are pleased to present 10 high-quality contributions...

This report discusses many-task computing (MTC), both generically and in the context of the proposed Blue Waters systems. Blue Waters is planned to be the largest supercomputer funded by NSF when it begins production use in 2011–2012 at NCSA. The aim of this report is to inform the Blue Waters project about MTC, including understanding aspects of MTC applications that can be used to characteriz...

Abstract This contribution applies the “mean temperature of catch” (MTC) concept Cheung et al. ( Nature 497:365–368, 2013) to fish catch data for Lake Peipsi, Estonia/Russia, covering years 1931 2019. The preferred each ten target species was obtained from literature, and combined with species-specific obtain MTC values year. analysis time series thus a segmented regression yielded two trend li...