PURPOSE To explore the possibility of the c-erbB2 oncogene antisense probe labeled with superparamagnetic iron oxide (SPIO) nanoparticles as a target contrast agent for magnetic resonance (MR) imaging whose morphology was observed with atomic force microscopy (AFM), and its efficiency was examined by MR imaging. METHODS The c-erbB2 oncogene antisense probe labeled with SPIO was synthesized by...

Atomic force microscopy (AFM) has evolved from the originally morphological imaging technique to a powerful and multifunctional technique for manipulating and detecting the interactions between molecules at nanometer resolution. However, AFM cannot provide the precise information of synchronized molecular groups and has many shortcomings in the aspects of determining the mechanism of the intera...

A model providing a semi-quantitative account for the magnetic behavior of Co nanoparticles embedded in a CoO matrix is presented. The results confirm that exchange coupling at the interface between FM and AFM nanostructures, could provide an extra source of magnetic anisotropy, leading to thermal stability of the FM nanoparticles. It is shown that perpendicular coupling between the AFM and FM ...

A method is presented to indirectly measure and shorten carbon nantoubes grown from the tips of atomic force microscope (AFM) probes. The measurement component exploits the nanotubes ability to elastically buckle and requires only those signals and actuators available on a standard AFM. The shortening operation is facilitated by electric arcing using a conducting niobium substrate. The shorteni...

Three-dimensional atom probe tomography (APT) is successfully used to analyze the near-apex regions of an atomic force microscope (AFM) tip. Atom scale material structure and chemistry from APT analysis for standard silicon AFM tips and silicon AFM tips coated with a thin film of Cu is presented. Comparison of the thin film data with that observed using transmission electron microscopy indicate...

Reproducible images of uncoated DNA in the atomic force microscope (AFM) have been obtained by imaging plasmid DNA on mica in n-propanol. Specially sharpened AFM tips give images with reproducible features several nanometers in size along the DNA. Plasmids can be dissected in propanol by increasing the force applied by the AFM tip at selected locations.

The principal habitats of immature Orthopodomyia alba and Orthopodomyia signifera are tree holes, though they are occasionally encountered in artificial containers. We collected 929 Or. alba and 17 Or. signifera from 2 plastic trash cans, 2 scrap tires, and a tree hole. All collections were made in an urban residential area in central Illinois.