Label Distribution Learning (LDL) is a general learning framework that assigns an instance to distribution over set of labels rather than single label or multiple labels. Current LDL methods have proven their effectiveness in many real-life machine applications. However, generalization the classification task and as such it exposed same problems standard algorithms, including class-imbalanced, ...

Introduction Astaxanthin (ASX) is carotenoid with the highest antioxidant activity in various cell types and reverse atherosclerosis. However, roles detailed mechanisms of ASX atherosclerosis associated endothelial injury remains unclear. Methods In vitro model was established HUVECs by incubation oxidized low-density lipoprotein (ox-LDL). Cell viability oxidative stress were measured. The mRNA...

The study was devoted to the of prevalence hypercholesterolemia (hyper-Chol) and low density lipoproteins (hyper-LDL-C) against background abdominal obesity (AO) in a population aged 25–44 years Novosibirsk. Material methods . A crosssectional survey Novosibirsk (Russia) carried out. 1415 people were examined, including 670 men (47.3 %) 745 women (52.7 %), pregnant or being on maternity leave n...

PURPOSE Modified (oxidized and/or glycated) low-density lipoproteins (LDLs) have been implicated in retinal pericyte loss, one of the major pathologic features of early-stage diabetic retinopathy. To delineate underlying molecular mechanisms, the present study was designed to explore the global effects of modified LDL on pericyte gene expression. METHODS Quiescent human retinal pericytes were...

Low density lipoprotein (LDL) isolated from human plasma anticoagulated with EDTA (EDTA/LDL) was 4-fold more resistant to oxidation by reagent H2O2, as assayed by the thiobarbituric acid (TBA) assay, than LDL prepared from plasma anticoagulated with citrate (CDP/LDL). The LDLs required 1-3 mM H2O2 for maximal oxidation by this assay, and ED50S were 1.7 X 10(-3) M for EDTA/LDL and 4.5 X 10(-4) M...

Studies of low density lipoprotein (LDL) metabolism in nonhuman model systems have indicated that the mammalian liver has dual mechanisms for the uptake and regulation of the concentration of plasma LDL. Heretofore, direct evaluation of lipoprotein uptake mechanisms in human hepatocytes has not been possible. In order to compare hepatocyte LDL uptake with fibroblast LDL metabolism, human hepato...

The presence in plasma of an electronegative LDL subfraction [LDL(-)] cytotoxic for endothelial cells (ECs) has been reported. We studied the effect of LDL(-) on the release by ECs of molecules implicated in leukocyte recruitment [interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1)] and in the plasminogen activator inhibitor-1 (PAI-1). LDL(-), isolated by anion-exchange chromatograp...

We investigated the interaction and transport of low-density lipoprotein (LDL) through the arterial endothelium in rat aorta and coronary artery, by perfusing in situ native, untagged human, and rat LDL. The latter was rendered electron-opaque after it interacted with the endothelial cell and was subsequently fixed within tissue. We achieved LDL electron-opacity by an improved fixation procedur...

Decreased plasma low density lipoprotein (LDL) particle size has been associated with premature coronary artery disease (CAD). We examined LDL particle size by 2-16% gradient gel electrophoresis in 275 men with CAD (>75% cross-sectional-area stenosis) and 822 controls. Seven major LDL size bands (with LDL-1 [d=1.025-1.033 g/ml] being the largest and LDL-7 [d= 1.050-1.063 g/ml, the smallest]) we...