König, Jörg, Yunhai Cui, Anne T. Nies, and Dietrich Keppler. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am. J. Physiol. Gastrointest. Liver Physiol. 278: G156–G164, 2000.—We cloned and expressed a new organic anion transporting polypeptide (OATP), termed human OATP2, (OATP-C, LST-1; symbol SLC21A6), involved in the uptake of various li...

Simaan, May, Serge Picard, Jean St-Louis and Michèle Brochu. Functional alteration of dihydropyridinesensitive Ca21 channels in the adrenal glomerulosa of pregnant rats. Am J Physiol Endocrinol Metab 278: E925–E932, 2000.—Our previous work on aldosterone secretion suggested that dihydropyridine-sensitive calcium channels, one type of voltage-dependent calcium channels (VDCC), are functionally i...

Pausawasdi, N., S. Ramamoorthy, V. Stepan, J. Del Valle, and A. Todisco. Regulation and function of p38 protein kinase in isolated canine gastric parietal cells. Am. J. Physiol. Gastrointest. Liver Physiol. 278: G24–G31, 2000.—We examined the regulation and functional role of p38 kinase in gastric acid secretion. p38 kinase was immunoprecipitated from cell lysates of highly purified gastric par...

Hilton, L. K., and A. B. Loucks. Low energy availability, not exercise stress, suppresses the diurnal rhythm of leptin in healthy young women. Am. J. Physiol. Endocrinol. Metab. 278: E43–E49, 2000.—Because the effect of exercise on leptin was not established, we controlled energy intake (I) and exercise energy expenditure (E) to distinguish the independent effects of energy availability (A 5 I ...

Kuemmerle, John F. Endogenous IGF-I regulates IGF binding protein production in human intestinal smooth muscle cells. Am J Physiol Gastrointest Liver Physiol 278: G710– G717, 2000.—Human intestinal smooth muscle in culture produces insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-3, IGFBP-4, and IGFBP-5, which modulate the effects of IGF-I. This study examined the regulation o...

STEPHEN M. WIENER,1 ROBERT F. HOYT, JR.,2 JOHN R. DELEONARDIS,2 RANDALL R. CLEVENGER,2 KENNETH R. JEFFRIES,2 KUNIO NAGASHIMA,3 MYRNA MANDEL,4 JENNIE OWENS,5 MICHAEL ECKHAUS,5 ROBERT J. LUTZ,6 AND BRIAN SAFER1 1Molecular Hematology Branch and 2Laboratory of Animal Medicine and Surgery, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda 20892; 3Laboratory of Cell a...

NICOLA L. JONES,1,2,3 AVINASH ISLUR,1 RIZWAN HAQ,4 MARIOLA MASCARENHAS,1 MOHAMED A. KARMALI,2 MARY H. PERDUE,5 BRENT W. ZANKE,4 AND PHILIP M. SHERMAN1,2,3 1Research Institute, Hospital for Sick Children, and Departments of 2Molecular Microbiology and Medical Genetics and 3Pediatrics, University of Toronto, Toronto M5G 1X8; 4Department of Medicine, University of Toronto, Princess Margaret Hospit...

Gupta, Gaurav, Jane A. Cases, Li She, Xiao-Hui Ma, Xiao-Man Yang, Meizu Hu, Jeanie Wu, Luciano Rossetti, and Nir Barzilai. Ability of insulin to modulate hepatic glucose production in aging rats is impaired by fat accumulation. Am J Physiol Endocrinol Metab 278: E985– E991, 2000.—Increased total fat mass (FM) and visceral fat (VF) may account in part for age-associated decrease in hepatic insul...

Moore, Beverley A., Gerald P. Morris, and Stephen Vanner. A novel in vitro model of Brunner’s gland secretion in the guinea pig duodenum. Am. J. Physiol. Gastrointest. Liver Physiol. 278: G477–G485, 2000.—A novel in vitro model that combined functional and morphological techniques was employed to directly examine pathways regulating Brunner’s gland secretion in isolation from epithelium. In vit...

Yamashita, Masatomo, and Mamoru Yamashita. Hyperbaric oxygen treatment attenuates cytokine induction after massive hemorrhage. Am J Physiol Endocrinol Metab 278: E811–E816, 2000.—We investigated the effect of hyperbaric oxygen treatment (HBO) on cytokine induction after hemorrhage, because hypoxia induces cytokines in vitro. Chronically cannulated conscious rats were subjected to 40 ml/kg of he...