In this commentary, Philip Hieter and Kym Boycott discuss the importance of model organisms for understanding pathogenesis of rare human genetic diseases, and highlight the work of Brooks et al., "Dysfunction of 60S ribosomal protein L10 (RPL10) disrupts neurodevelopment and causes X-linked microcephaly in humans," published in this issue of GENETICS.

BACKGROUND Benchmark dose (BMD) modeling computes the dose associated with a prespecified response level. While offering advantages over traditional points of departure (PODs), such as no-observed-adverse-effect-levels (NOAELs), BMD methods have lacked consistency and transparency in application, interpretation, and reporting in human health assessments of chemicals. OBJECTIVES We aimed to ap...

در این کار پژوهشی، نمونه‌های هیدروکسی اپتایت آلاییده با ناخالصی‌های سریم، گادولونیم و ترکیبی از دو ناخالصی به روش هیدروترمال سنتز شدند. منظور بررسی فازهای بلوری تشکیل یافته هرکدام شده، کد MAUD که یک نرم‌افزار برای تجزیه تحلیل ساختار ماده استفاده پراش بر اساس ریتولد است، شد. پاسخ دزیمتری ترمولومینسانس نمونه‌ها مورد قرار گرفت یافته‌ها نشان داد نمونه‌ ترکیبی، سطح میانی است. مشخص شد افزودن سریم می‌...

We introduce and justify a taxonomy for the structure of markets and minimal institutions which appear in constructing minimally complex trading structures to perform the functions of price formation, settlement and payments. Each structure is presented as a playable strategic market game and is examined for its efficiency, the number of degrees of freedom and the symmetry properties of the str...

This paper examines the empirical validity of a model of homogeneous input demand under price uncertainty in which firms trade off expected input cost against its variability (risk) in selecting the optimal input supplier mix. Using recent work in time-series econometrics, this model is applied to the Japanese steam-coal import market, where five suppliers compete: China, the Soviet Union, Sout...

Pindolol is a beta blocker which helps to lower blood pressure and may possibly also alleviate depression. With potentially even more uses for this drug product it is important to develop faster analyses of it. Using pindolol and a USP method, this study demonstrates how use of short HPLC columns packed with sub-2-micron support particles (ZORBAX SB-CN (L10) columns) provide easy scalability to...

Rawcliffe, AJ, Simpson, RJ, Graham, SM, Psycharakis, SG, Moir, GL, and Connaboy, C. Reliability of the kinetics of British Army foot drill in untrained personnel. J Strength Cond Res 31(2): 435-444, 2017-The purpose of this study was to quantify the reliability of kinetic variables of British Army foot drill performance within untrained civilians and report the magnitude of vertical ground reac...