نتایج جستجو برای: روکش استنلس استیل ssc
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در این پژوهش از فرایند جوش کاری قوسی تنگستن برای روکش کاری1 و ترمیم سطح آلیاژ ریختگی منیزیم c91az استفاده شد. در ادامه برای بررسی تأثیر بهبود خواص ریزساختاری بر خواص سایشی، فرایند اصطکاکی اغتشاشی و عملیات حرارتی t6 بر ناحیه روکش کاری شده، اعمال شد. نتایج ریزسختی سنجی گویای افزایش میانگین سختی با فرایند روکش کاری و سپس افزایش سختی ناحیه روکش کاری شده با فرایند اصطکاکی اغتشاشی و در نهایت افزایش ب...
Introduction Systemic sclerosis (ssc) is a rare multisystemic disease characterized by inflammation, vascular abnormalities, and fibrosis that affects the skin and various internal organs. Juvenile ssc accounts for fewer than 10% of all adults with ssc. Regarding effective treatment there were no specific pediatric data available, and the long-term efficacy of treatment for children with ssc ha...
The factors responsible for maintaining persistent organ fibrosis in systemic sclerosis (SSc) are not known but emerging evidence implicates toll-like receptors (TLRs) in the pathogenesis of SSc. Here we show the expression, mechanism of action and pathogenic role of endogenous TLR activators in skin from patients with SSc, skin fibroblasts, and in mouse models of organ fibrosis. Levels of tena...
It is unclear whether any clinical and laboratory features are associated with pulmonary fibrosis (PF) in systemic sclerosis (SSc). We assessed these features using a database of 29 patients with SSc and anti-topoisomerase I antibodies and 68 patients with SSc and anticentromere antibody (ACA). Clinical features were not associated with the incidence of PF in patients with SSc and anti-topoisom...
BACKGROUND Systemic sclerosis (SSc) is characterized by autoantibodies against various cellular components. OBJECTIVE To determine the presence or levels of antibodies (Abs) against a protease domain (PD) of caspase-8 and their clinical relevance in SSc. METHODS Anti-caspase-8 PD Ab was examined by enzyme-linked immunosorbent assay and immunoblotting using human recombinant caspase-8 PD. Ca...
INTRODUCTION Obliterative vasculopathy and fibrosis are hallmarks of systemic sclerosis (SSc), a severe systemic autoimmune disease. Bone marrow-derived mesenchymal stromal cells (MSCs) from SSc patients may harbor disease-specific abnormalities. We hypothesized disturbed vascular smooth muscle cell (VSMC) differentiation with increased propensity towards myofibroblast differentiation in respon...
Systemic sclerosis (SSc) IgGs affecting the M(3)-muscarinic receptor (M(3)-R) have been proposed to be responsible for the gastrointestinal (GI) dysmotility in this disease. However, the effect of SSc IgGs on smooth muscle cell (SMC) function has not been studied. We determined the effect of SSc IgGs on the muscarinic receptor activation by bethanechol (BeCh; methyl derivate of carbachol) in SM...
OBJECTIVE To determine the genetic, clinical and serological characteristics of systemic sclerosis (SSc)-rheumatoid arthritis (RA) overlap syndrome. METHODS Clinical manifestations and immunolaboratory features of 22 SSc-RA patients were assessed. The HLA-DR genotype of the 22 SSc-RA patients determined by SSP-PCR was compared with that of 38 SSc patients, 100 RA patients and 50 healthy contr...
The aim was to update the 2009 European League against Rheumatism (EULAR) recommendations for the treatment of systemic sclerosis (SSc), with attention to new therapeutic questions. Update of the previous treatment recommendations was performed according to EULAR standard operating procedures. The task force consisted of 32 SSc clinical experts from Europe and the USA, 2 patients nominated by t...
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