Tenascin-C (TN-C) is induced in pulmonary vascular disease, where it colocalizes with proliferating smooth muscle cells (SMCs) and epidermal growth factor (EGF). Furthermore, cultured SMCs require TN-C for EGF-dependent growth on type I collagen. In this study, we explore the regulation and function of TN-C in SMCs. We show that a matrix metalloproteinase (MMP) inhibitor (GM6001) suppresses SMC...

OBJECT Trigeminal neuralgia (TN) presents a diagnostic challenge because of the variety of symptoms, findings during microvascular decompression (MVD), and postsurgical outcomes observed among patients who suffer from this disorder. Recently, a new paradigm for classification of TN was proposed, based on the quality of pain. This study represents the first clinical analysis of this paradigm. ...

Total nitrogen (TN) and total phosphorus (TP) measurements and contemporaneous measurements of chlorophyll a (Chl a) and phytoplankton nutrient deficiency have been made across a broad range of lakes and ocean sites using common methods. The ocean environment was nutrient rich in terms of TN and TP when compared with most lakes in the study, although Lake Victoria had the highest values of TN a...

Let G be a graph with p vertices and q edges and A = {0, 1, 2, . . . , [q/2]}. A vertex labeling f : V (G) → A induces an edge labeling f∗ defined by f∗(uv) = f(u) + f(v) for all edges uv. For a ∈ A, let vf (a) be the number of vertices v with f(v) = a. A graph G is said to be vertex equitable if there exists a vertex labeling f such that for all a and b in A, |vf (a) − vf (b)| ≤ 1 and the indu...

let g be a graph with p vertices and q edges and a = {0, 1, 2, . . . , [q/2]}. a vertex labeling f : v (g) → a induces an edge labeling f∗ defined by f∗(uv) = f(u) + f(v) for all edges uv. for a ∈ a, let vf (a) be the number of vertices v with f(v) = a. a graph g is said to be vertex equitable if there exists a vertex labeling f such that for all a and b in a, |vf (a) − vf (b)| ≤ 1 and the in...

BACKGROUND Matrix metalloproteinase-9 (MMP-9) and Tenascin-C (TN-C) have been shown to be involved in the metastasis of many tumors. The purpose of this study was to determine the relationship between the co-expression of these two molecules and the clinical prognosis of pancreatic cancer. METHODS We investigated the expression of TN-C and MMP-9 in 103 pancreatic cancer tissues by immunohisto...

BACKGROUND Tenascin-C (TN-C), an extracellular matrix glycoprotein, appears at several important steps of cardiac development in the embryo, but is sparse in the normal adult heart. TN-C re-expresses under pathological conditions including myocarditis, and is closely associated with tissue injury and inflammation in both experimental and clinical settings. However, the pathophysiological role o...